Joshua Rubin, MD, PhD

Joshua Rubin, MD, PhD

Pediatric Hematologist/ Oncologist

Primary Academic Title

Professor of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine

Clinical Expertise

Pediatric brain tumors

Research Interest

Normal neuronal precursor cell proliferation, survival and migration in order to identify pathways that are likely to contribute to the genetics of pediatric brain tumors. We described a critical role for the chemokine receptor CSCR4 in normal cerebellar development and malignant brain tumor growth. This requirement creates a unique vulnerability in cancer growth to CXCR4 blockade, and we hope to exploit this in novel treatments for pediatric and adult patients with brain tumors.

Education

  • 1992: MSc, neuroscience, Albert Einstein College of Medicine, New York
  • 1994: MD/PhD, neuroscience, Albert Einstein College of Medicine

Training

  • 1994 - 1997: Resident, Children's Hospital and Harvard University, Boston
  • 1997 - 2000: Clinical fellow, hematology/oncology, Children's Hospital and Dana-Farber Cancer Institute, Boston

Board Certification

  • 2000: American Board of Pediatrics, Pediatric Hematology/Oncology

Selected Research Publications

Failure of human rhombic lip differentiation underlies medulloblastoma formation.
  • Hendrikse LD, Haldipur P, Saulnier O, [...] Rubin JB, [...] Taylor MD
  • Nature 2022
Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma.
  • Broestl L, Warrington NM, Grandison L, [...] Rubin JB
  • Commun Biol 2022
Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis.
  • Rockwell NC, Yang W, Warrington NM, [...] Rubin JB
  • Cancer Res Commun 2021
Subgroup and subtype-specific outcomes in adult medulloblastoma.
  • Coltin H, Sundaresan L, Smith KS, [...] Rubin JB, [...] Ramaswamy V
  • Acta Neuropathol 2021
Sex disparities matter in cancer development and therapy.
  • Haupt S, Caramia F, Klein SL, Rubin JB , Haupt Y
  • Nat Rev Cancer 2021
Molecular omics resources should require sex annotation: a call for action.
  • Bond KM, McCarthy MM, Rubin JB, Swanson KR
  • Nat Methods 2021
Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma.
  • Kfoury N, Qi Z, Prager BC, [...] Rubin JB
  • Proc Natl Acad Sci USA 2021
Sex- and Gender-Based Pharmacological Response to Drugs.
  • Mauvais-Jarvis F, Berthold HK, Campesi I, [...] Rubin JB
  • Pharmacol Rev 2021
The transcriptional landscape of Shh medulloblastoma.
  • Skowron P, Farooq H, Cavalli FMG, [...] Rubin JB, [...] Taylor MD
  • Nat Commun 2021

View All Publications

Contact Information

  • Washington University Medical Campus

    4921 Parkview Place
    Saint Louis, MO 63110

  • Siteman Kids at St. Louis Children’s Hospital

    1 Children's Place
    St. Louis, MO 63110

Phone Numbers

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