Lavinia Sheets, PhD

Lavinia Sheets, PhD

Head and Neck

Primary Academic Title

Associate Professor, Department of Otolaryngology - Head & Neck Surgery, Washington University School of Medicine

Research Interest

Cisplatin is an effective and widely used antineoplastic drug. But it is also associated with toxic side effects, including neuropathy and permanent hearing loss. My research group has optimized a zebrafish model ototoxicity and neurotoxicity with the goal of uncovering therapeutic strategies to protect sensory hair cells and nerve fibers from damage during cisplatin-based chemotherapy.

Education

  • 2007: PhD, Oregon Health & Science University

Training

  • 2007 - 2013: Postdoctoral Research Associate; Molecular Basis of Hearing and Balance, Howard Hughes Medical Institute, Oregon Hearing Research Center and Collum Institute, Portland, Oregon
  • 2013 - 2015: Amelia Peabody Research fellow, Independent Investigator , Massachusetts Eye and Ear Infirmary, Harvard Medical School
  • 2015 - 2017: Instructor , Massachusetts Eye and Ear Infirmary, Harvard Medical School

Selected Research Publications

Cisplatin drives mitochondrial dysregulation in sensory hair cells.
  • Lee DS, Schrader A, Zou J, [...] Sheets L
  • bioRxiv 2024
Evaluation of Cisplatin-Induced Pathology in the Larval Zebrafish Lateral Line.
  • Lee DS, Schrader A, Bell E, Warchol ME, Sheets L
  • Int J Mol Sci 2022

View All Publications