David Spencer, MD, PhD

David Spencer, MD, PhD

Primary Academic Title

Assistant Professor, Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine

Research Interest

My research program studies epigenetic gene regulation in cancer, with a specific emphasis on understanding how mutations in acute myeloid leukemia (AML) perturb the epigenome to alter gene expression and cause leukemia.


  • 2008: PhD, University of Washington, Seattle
  • 2010: MD, University of Washington


  • 2010 - 2011: Chief resident, clinical pathology, Barnes-Jewish Hospital, St. Louis

Selected Research Publications

Missense mutations in Myc Box I influence nucleocytoplasmic transport to promote leukemogenesis.
  • Arthur NB, Christensen KA, Mannino K, [...] Spencer DH, [...] Ferraro F
  • Clin Cancer Res 2024
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
  • Issa N, Bjeije H, Wilson ER, [...] Spencer DH, Challen GA
  • Leukemia 2023
Clonal dynamics of haematopoiesis across the human lifespan.
  • Mitchell E, Spencer Chapman M, Williams N, [...] Spencer DH, [...] Campbell PJ
  • Nature 2022
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
  • Wilson ER, Helton NM, Heath SE, [...] Spencer DH
  • Leukemia 2022
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia.
  • Berrien-Elliott MM, Foltz JA, Russler-Germain DA, [...] Spencer DH, [...] Fehniger TA
  • Sci Transl Med 2022
Heterozygous variants of CLPB are a cause of severe congenital neutropenia.
  • Warren JT, Cupo RR, Wattanasirakul P, Spencer D, [...] Link DC
  • Blood 2022
Tumor suppressor function of WT1 in acute promyelocytic leukemia.
  • Christopher MJ, Katerndahl CDS, LeBlanc HR, [...] Spencer DH, [...] Ley TJ
  • Haematologica 2022
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
  • Ferraro F, Miller CA, Christensen KA, [...] Spencer DH, [...] Ley TJ
  • Proc Natl Acad Sci USA 2021