David Spencer, MD, PhD

David Spencer, MD, PhD

Primary Academic Title

Associate Professor, Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine

Research Interest

My research program studies epigenetic gene regulation in cancer, with a specific emphasis on understanding how mutations in acute myeloid leukemia (AML) perturb the epigenome to alter gene expression and cause leukemia.

Education

  • 2008: PhD, University of Washington, Seattle
  • 2010: MD, University of Washington

Training

  • 2010 - 2011: Chief resident, clinical pathology, Barnes-Jewish Hospital, St. Louis

Selected Research Publications

Innovations in Short-Read Sequencing Technologies and Their Applications to Clinical Genomics.
  • Polonis K, Blommel JH, Hughes AEO, Spencer D, [...] Schroeder MC
  • Clin Chem 2025
Regulatory Considerations for Genome-Edited T-cell Therapies.
  • Jadlowsky JK, Chang JF, Spencer DH, [...] Singh N
  • Cancer Immunol Res 2024
Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis.
  • Arthur NBJ, Christensen KA, Mannino K, [...] Spencer DH, [...] Ferraro F
  • Clin Cancer Res 2024
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
  • Issa N, Bjeije H, Wilson ER, [...] Spencer DH, Challen GA
  • Leukemia 2023
Clonal dynamics of haematopoiesis across the human lifespan.
  • Mitchell E, Spencer Chapman M, Williams N, [...] Spencer DH, [...] Campbell PJ
  • Nature 2022