David Spencer, MD, PhD

David Spencer, MD, PhD

Primary Academic Title

Associate Professor, Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine

Research Interest

My research program studies epigenetic gene regulation in cancer, with a specific emphasis on understanding how mutations in acute myeloid leukemia (AML) perturb the epigenome to alter gene expression and cause leukemia.

Education

  • 2008: PhD, University of Washington, Seattle
  • 2010: MD, University of Washington

Training

  • 2010 - 2011: Chief resident, clinical pathology, Barnes-Jewish Hospital, St. Louis

Selected Research Publications

Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers.
  • Abel HJ, Mahgoub M, Davarapalli N, [...] Spencer DH
  • J Mol Diagn 2025
Intermediately Methylated Regions in Normal Cells Are Epimutation Hotspots in Cancer.
  • Mahgoub M, Abel H, Davarapalli N, [...] Spencer DH
  • bioRxiv 2025
Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis.
  • Arthur NBJ, Christensen KA, Mannino K, [...] Spencer DH, [...] Ferraro F
  • Clin Cancer Res 2024