Hussein Sultan, PhD

Hussein Sultan, PhD

Primary Academic Title

Assistant Professor, Department of Pathology & Immunology, Washington University School of Medicine

Research Interest

My utmost motivation lies in enhancing the safety and effectiveness of cancer immunotherapy, with specific emphasis on personalized neoantigen cancer vaccines. My research focuses on two main areas: 1-Define the intrinsic and extrinsic factors that lead to the induction/development of type 1 regulatory T cells and unravel the mechanisms involved in their suppressive activity. 2-Develop novel vaccination strategies that promote the induction of effector anti-tumor T cells while avoiding the generation of suppressive T-cell responses that promote tumor progression.

Education

  • 2008: BSPS, School of Pharmacy, Cairo University, Cairo, Egypt
  • 2017: PhD, Augusta University/Medical College of Georgia, Augusta, GA

Training

  • 2018 - 2023: Postdoctoral research scholar, Robert Schreiber Lab, Department of pathology and immunology, Washington University School of Medicine, St. Louis, MO

Selected Research Publications

Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.
  • Sultan H, Takeuchi Y, Ward JP, [...] Schreiber RD
  • Nature 2024
Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry.
  • Meng W, Takeuchi Y, Ward JP, Sultan H, [...] Schreiber RD
  • Cancer Immunol Res 2024
IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity.
  • Moynihan KD, Kumar MP, Sultan H, [...] Djuretic IM
  • Cancer Discov 2024