Stephen Sykes, PhD

Stephen Sykes, PhD

Primary Academic Title

Associate Professor of Pediatrics, Division of Hematology/Oncology, Washington University School of Medicine

Research Interest

Identifying and defining those molecular features that drive leukemogenesis and then use that information to develop rational therapeutic strategies for improving outcomes in acute leukemia.


  • 2007: PhD, cellular and molecular biology, University of Pennsylvania, Philadelphia


  • 2008 - 2009: Postdoctoral fellow, hematology, Brigham & Women's Hospital, Boston
  • 2009 - 2012: Postdoctoral fellow, regenerative medicine, Massachusetts General Hospital, Boston

Selected Research Publications

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
  • Vekariya U, Toma M, Nieborowska-Skorska M, [...] Sykes S, [...] Skorski T
  • Blood 2023
The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm.
  • Zhang Y, Truong B, Fahl SP, [...] Sykes S, [...] Wiest DL
  • Blood 2022
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
  • Maifrede S, Le BV, Nieborowska-Skorska M, [...] Sykes SM, [...] Skorski T
  • Cancer Res 2021

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