Daniel Thorek, PhD

Daniel Thorek, PhD

Primary Academic Title

Associate Professor of Radiology, Division of Radiological Chemistry and Imaging Laboratory, Washington University School of Medicine

Research Interest

Our laboratory focuses on characterizing disease on a molecular and functional level for the precise application of targeted therapies. Noninvasive imaging and ex vivo profiling provide a basis for the development and monitoring of novel mono- and combination therapy approaches in model systems that recapitulate features of advanced disease.

Education

  • 2009: PhD, bioengineering, University of Pennsylvania, Philadelphia

Selected Research Publications

High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance.
  • Saeed MA, Peng B, Kim K, [...] Thorek DLJ, [...] Pachynski RK
  • Cancer Immunol Res 2024
Molecular Imaging of ACE2 Expression in Infectious Disease and Cancer.
  • Li Z, Hasson A, Daggumati L, Zhang H, Thorek DLJ
  • Viruses 2023
Evaluation of Candidate Theranostics for 227Th/89Zr Paired Radioimmunotherapy of Lymphoma.
  • Abou DS, Longtine M, Fears A, [...] Thorek DLJ
  • J Nucl Med 2023
Cure of Disseminated Human Lymphoma with [225Ac]Ac-Ofatumumab in a Preclinical Model.
  • Longtine MS, Shim K, Hoegger MJ, [...] Thorek DLJ, Wahl RL
  • J Nucl Med 2023
Cure of Disseminated Human Lymphoma with [177Lu]Lu-Ofatumumab in a Preclinical Model.
  • Shim K, Longtine MS, Abou DS, [...] Thorek DL, Wahl RL
  • J Nucl Med 2023
IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry.
  • Lu P, Oetjen KA, Bender DE, [...] Thorek DLJ
  • Nat Commun 2023
Radiochemical Quality Control Methods for Radium-223 and Thorium-227 Radiotherapies.
  • Hasson A, Jiang W, Benabdallah N, [...] Thorek DLJ
  • Cancer Biother Radiopharm 2023
Radiopharmaceutical Quality Control Considerations for Accelerator-Produced Actinium Therapies.
  • Abou DS, Zerkel P, Robben J, [...] Thorek DLJ
  • Cancer Biother Radiopharm 2022

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