Jason Weber, PhD

Jason Weber, PhD

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Molecular Oncology, Washington University School of Medicine

Research Interest

The p53 protein requires communication between upstream activators in order to sense when a cell is under stress. One such activator is the ARF tumor supressor. These two proteins are among the most frequently affected genes in human cancer. We are interested in understanding the individual contribution of these proteins to the development of human cancers and how they may be regulated by upstream signals.

Education

  • 1997: PhD, cell and molecular biology, Saint Louis University

Training

  • 1997 - 2001: Postdoctoral associate, Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tenn.

Selected Research Publications

ADAR1 Regulates Lipid Remodeling through MDM2 to Dictate Ferroptosis Sensitivity.
  • Kung CP, Terzich ND, Ilagen MXG, [...] Weber JD
  • bioRxiv 2025
ADAR1 Regulates Lipid Remodeling through MDM2 to Dictate Ferroptosis Sensitivity.
  • Kung CP, Terzich ND, Ilagen MXG, [...] Weber JD
  • bioRxiv 2025
Activation of PKR by a short-hairpin RNA.
  • Cottrell KA, Ryu S, Donelick H, [...] Weber JD
  • Sci Rep 2024
Activation of PKR by a short-hairpin RNA.
  • Cottrell KA, Ryu S, Donelick H, [...] Weber JD
  • Sci Rep 2024
Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells.
  • Cottrell KA, Ryu S, Pierce JR, [...] Weber JD
  • Cancer Res Commun 2024
Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells.
  • Cottrell KA, Ryu S, Pierce JR, [...] Weber JD
  • Cancer Res Commun 2024
Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells.
  • Cottrell KA, Ryu S, Torres LS, Schab AM, Weber JD
  • bioRxiv 2023
Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells.
  • Cottrell KA, Ryu S, Torres LS, Schab AM, Weber JD
  • bioRxiv 2023

View All Publications