William Chapman, MD, FACS

Surgeon

Primary Academic Title

Eugene M. Bricker Chair of Surgery and Chief, Division of General Surgery and Section of Transplant Surgery, Washington University School of Medicine

Clinical Expertise

As chief of the Section of Transplant Surgery and chief of the Division of General Surgery, Dr. Chapman is committed to providing patients with exceptional liver cancer care. Learn more about how Dr. Chapman and our liver cancer speclialist team approach diagnosis and staging, treatment and recovery.

Research Interest

1) Image-guided liver surgery: Development and application of techniques for image guidance in resectional ablative liver surgery. 2) Multisystem inflammation following hapatic injury: This project investigates consequences of hepatic injury and response to direct liver injury. 3) Enhanced treatment of hepatocellular carcinoma.

Education

1984: MD, Medical University of South Carolina, Charleston

Training

1984 - 1987: Resident, surgery, Vanderbilt University, Nashville, Tenn.
1987 - 1989: Research fellow, hepatobiliary disease, Vanderbilt University
1990 - 1991: Chief resident,general surgery, Vanderbilt University
1991 - 1992: Fellow, hepatobiliary surgery and liver transplantation, Kings College Hospital, London

Board Certification

2001: American Board of Surgery, Surgery
2001: American Board of Surgery, Surgical Critical Care

Selected Research Publications

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.

Cotto KC, Feng YY, Ramu A, [...] Chapman WC, [...] Griffith M
Nat Commun 2023

Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study.

Breuer E, Mueller M, Doyle MB, [...] Chapman WC, [...] Clavien PA
Ann Surg 2022

Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma.

Tabrizian P, Holzner ML, Mehta N, [...] Chapman WC, [...] Llovet JM
JAMA Surg 2022

Cost-effectiveness of Total Neoadjuvant Therapy With Short-Course Radiotherapy for Resectable Locally Advanced Rectal Cancer.

Chin RI, Otegbeye EE, Kang KH, [...] Chapman WC, [...] Kim H
JAMA Netw Open 2022

Total Neoadjuvant Therapy With Short-Course Radiation: US Experience of a Neoadjuvant Rectal Cancer Therapy.

Chapman WC, Kim H, Bauer P, [...] Hunt SR
Dis Colon Rectum 2022

Development and Assessment of a Clinical Calculator for Estimating the Likelihood of Recurrence and Survival Among Patients With Locally Advanced Rectal Cancer Treated With Chemotherapy, Radiotherapy, and Surgery.

Weiser MR, Chou JF, Keshinro A, Chapman WC, [...] Gönen M
JAMA Netw Open 2021

A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion.

Xu M, Zhou F, Ahmed O, [...] Chapman WC
Transplantation 2021

Optimal Timing of Administration of Direct-acting Antivirals for Patients With Hepatitis C-associated Hepatocellular Carcinoma Undergoing Liver Transplantation.

Turgeon MK, Shah SA, Delman AM, [...] Chapman WC, Maithel SK
Ann Surg 2021

Enucleation of Biliary Cystadenomas: a Review.

Strasberg SM, Chapman WC
J Gastrointest Surg 2021

Proposal of a New Comprehensive Notation for Hepatectomy: The "New World" Terminology.

Nagino M, DeMatteo R, Lang H, [...] Chapman W, [...] Clavien PA
Ann Surg 2021

Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma.

Halazun KJ, Rosenblatt RE, Mehta N, [...] Chapman W, Sapisochin G
JAMA Surg 2021

Assessing Rectal Cancer Treatment Response Using Coregistered Endorectal Photoacoustic and US Imaging Paired with Deep Learning.

Leng X, Uddin KMS, Chapman W, [...] Zhu Q
Radiology 2021

Multicenter validation of the liver graft assessment following transplantation (L-GrAFT) score for assessment of early allograft dysfunction.

Agopian VG, Markovic D, Klintmalm GB, [...] Chapman WC, [...] Busuttil RW
J Hepatol 2021

Clinical Calculator Based on Molecular and Clinicopathologic Characteristics Predicts Recurrence Following Resection of Stage I-III Colon Cancer.

Weiser MR, Hsu M, Bauer PS, Chapman WC, [...] Gonen M
J Clin Oncol 2021

Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria.

Kardashian A, Florman SS, Haydel B, [...] Chapman WC, [...] Agopian VG
Hepatology 2020

Contact Information

Washington University Medical Campus

4921 Parkview Place
Saint Louis, MO 63110

Phone Numbers

Appointments: (314) 747-7222
Toll Free: (800) 600-3606

Request an appointment