Wayne Yokoyama, MD

Wayne Yokoyama, MD

Primary Academic Title

Sam J. Levin and Audrey Loew Levin Chair for Research of Arthritis; Professor of Medicine; and Chief, Division of Rheumatology, Washington University School of Medicine

Research Interest

Our current work is focused on determining the molecular basis for NK cell recognition of their tumor or infected targets and using this understanding to dissect the role of NK cells in tumor induction, viral infection and bone marrow transplantation in vitro and in vivo.


  • 1978: MD, University of Hawaii, Honolulu


  • 1978 - 1981: Resident, internal medicine, University of Iowa, Iowa City
  • 1981 - 1982: Clinical fellow, rheumatology, University of Iowa, Iowa City
  • 1982 - 1985: Research fellow, rheumatology, University of Iowa, Iowa City
  • 1985 - 1989: Research fellow, immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Md.

Selected Research Publications

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
  • Rožmanić C, Lisnić B, Pribanić Matešić M, [...] Yokoyama WM, [...] Brizić I
  • Nat Commun 2023
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC.
  • Baer JM, Zuo C, Kang LI, [...] Yokoyama WM, [...] DeNardo DG
  • Nat Immunol 2023
NK Cells and ILC1s in Cancer Biology.
  • Sliz A, Yokoyama WM
  • Adv Exp Med Biol 2022
Hobit confers tissue-dependent programs to type 1 innate lymphoid cells.
  • Yomogida K, Bigley TM, Trsan T, [...] Yokoyama WM, [...] Colonna M
  • Proc Natl Acad Sci USA 2021

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