castration-resistant prostate cancer

Definition of castrate-resistant prostate cancer
National Cancer Institute

castrate-resistant prostate cancer

(KAS-trayt-reh-ZIH-stunt PROS-tayt KAN-ser)
Prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low levels. Many early-stage prostate cancers need normal levels of testosterone to grow, but castrate-resistant prostate cancers do not. Also called CRPC.

Source: NCI Dictionary of Cancer Terms