Zhongsheng You Photo

Zhongsheng You, PhD

My lab studies the molecular mechanisms of genome maintenance in human cells. A major focus of our current work is to further dissect this novel signaling pathway, in particular, the ion channel(s) and signal transducers responsible for Ca2+ induction after replication stress for genome protection.

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Jieya Shao, PhD

My lab is broadly interested in uncovering novel and clinically relevant drivers and targets of cancer with the overarching goal of improving patient outcome. Our current major research effort is focused on understanding the mechanisms of action and therapeutic potentials of two multi-functional proteins (the actin-binding protein Profilin-1 and the AAA+ ATPase p97/VCP) in the contexts of genome stability maintenance and chemotherapy efficacy.

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Susana Gonzalo, PhD

My lab focuses on three areas of research: 1) Uncovering essential roles for lamins in DNA repair, DNA replication, and telomere structure, length and function; 2) Identifying new mechanisms underlying Hutchinson Gilford Progeria Syndrome (HGPS) pathology; and 3) Defining the relationship between lamins loss and oncogenic mechanisms, particularly in cancers with poor prognoses such as BRCA-mutated and triple negative breast cancers.

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Mary Mullen

Mary Mullen, MD

My lab’s current goal is to identify a biomarker predictive of tumor sensitivity to DNA damaging agents and to identify kinases and deubiquitinases involved in ovarian cancer resistance to DNA damaging agents. My lab is also focused on utilizing RAD51, a protein involved in homologous recombination, to create a functional biomarker for homologous recombination deficiencies. We hope to use this information to develop personalized treatment strategies for ovarian cancer which will minimize toxicity and optimize efficacy.

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Jeffrey Bednarski, MD, PhD

My lab investigates signaling networks that regulate hematopoiesis and lymphopoiesis and how alterations in these pathways lead to immune deficiencies or transformation into lymphoid malignancy. In particular, we’re interested in how signals from DNA damage cooperate with other developmental processes to direct hematopoietic cell differentiation and survival. We’re also interested in understanding how errors in DNA damage responses lead to aberrant immune development and immune deficiencies.

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Korolev Sergey

Sergey Korolev, PhD

My laboratory investigates structure and mechanism of pro- and eukaryotic DNA repair proteins and recombination mediator proteins (RMPs) to understand basic principles of nucleic acids metabolism and to advance novel therapy. Analysis of proteins from different kingdoms of life lead to discoveries of new fundamental mechanisms. We also collaborate with other research groups, providing our expertise in structural biology.

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Eric Greer

Eric Greer, PhD

My lab is interested in how non-genetic information, termed epigenetics, regulates complex physiological and pathological phenotypes across generations. Our research aims to determine how this epigenetic information is regulated, how it instructs biological outcomes, and how this epigenetic information can be passed from generation to generation. Other work in our lab focuses on identifying new epigenetic and epitranscriptomic regulators and the biological consequences of these post-transcriptional and post-translational modifications.

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Edwin Antony

Edwin Antony, PhD

My lab investigates the underlying molecular principles of how protein complexes function together to protect genomic integrity. Our perspective centers around Replication Protein A (RPA), a single-strand DNA binding protein that coats the DNA during various DNA metabolic processes including replication, repair, recombination, and DNA repair.

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Sergei Djuranovic

Sergei Djuranovic, PhD

My lab focuses on elucidating the sequence of cellular events that govern microRNA (miRNA)- or RBP- mediated gene regulation using biochemical and biophysical assays, high throughput methods, genome-wide analyses and rigorous kinetic and biochemical assays of protein expression and targeted mRNA degradation. We use similar methods to assess other cellular processes governed by mRNA or protein sequence motifs that are thought to affect RNA metabolism.

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Robert Galletto

Roberto Galletto, PhD

My lab studies how a class of DNA helicases, the Pif1-family, aids DNA replication at barriers imparted by DNA secondary structure and protein that are tightly bound to DNA. In this context, we have a special interest in how the nucleoprotein formed at telomeres are assembled and how Pif1 helicases impact their maintenance.

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Sofia Origanti

Sofia Origanti, PhD

My lab investigates the mechanism of large 60S ribosomal subunit maturation and the interplay of ribosomal stress and genomic stress responses. We are specifically interested in the translational control of cancers and ribosomopathies.  We are also interested in signaling networks that modulate homologous recombination-mediated DNA repair and chromosomal integrity.

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