Core B: Bioinformatics and Biostatistics

Directors:

Graham A. Colditz, MD, DRPh (WashU Medicine)

Malachi Griffith, PhD (WashU Medicine)

The Bioinformatics and Biostatistics Core (Core B) will support four leukemia research projects within this SPORE. The primary aim of Core B is to provide robust bioinformatics and statistical support to ensure rigorous and reproducible multi-omics analyses across preclinical studies, clinical trials, and clinical correlative studies. Core B’s services include guiding experimental design, data processing, and comprehensive analysis for a range of data types, including bulk RNA-seq, single-cell RNA-seq, CITE-seq, TCR-seq, whole genome sequencing (WGS), whole genome bisulfite sequencing (WGBS), ATAC-seq, scATAC-seq, CRISPR/Cas9 screens, and CyTOF experiments. By leveraging advanced bioinformatics tools and statistical methodologies, Core B enhances the precision and depth of data interpretation. In supporting the projects, Core B will enhance understanding of new treatment avenues pursued by each project including chimeric antigen receptor T-cell (CART) therapy for T-cell cancers, natural killer (NK) cell therapy for acute myeloid leukemia (AML), and targeted therapies for specific gene mutations in myeloid cancers. Through rigorous design and analysis of clinical trials and preclinical studies, Core B ensures that each project achieves its scientific objectives. Core B fosters a collaborative environment, offering consultation and training to researchers, thereby promoting the effective application of bioinformatics and biostatistics in leukemia research.