Clinical Trials

201510016

A Phase II Study of sEphB4-HSA in Kaposi Sarcoma Phase II Principal Investigator Ratner, Lee Disease Site Soft Tissue Learn more about this study at: clinicaltrials.gov

201510049

A Non-Inferiority Study of Doxorubicin with Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Phase II Principal Investigator Van Tine, Brian Disease Site Soft Tissue Learn more about this study at:…

201601048

Phase 1 study evaluating combination therapy with the receptor tyrosine kinase inhibitor Pexidartinib (PLX3397) and Sirolimus in patients with unresectable sarcoma and Phase 2 study in malignant peripheral nerve sheath tumors. Phase I/II Principal Investigator…

201601074

A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects with INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Phase II (Cancer Control) Principal Investigator Van Tine, Brian Disease Site Bones and Joints Learn…

201607078

A Pilot Study of Nelfinavir for the Treatment of Kaposi Sarcoma A Trial of the AIDS Malignancy Consortium (AMC)

201704069

A PHASE 1/2, OPEN-LABEL, DOSE-ESCALATION AND EXPANSION STUDY OF ENTRECTINIB (RXDX-101) IN PEDIATRICS WITH LOCALLY ADVANCED OR METASTATIC SOLID OR PRIMARY CNS TUMORS AND/OR WHO HAVE NO SATISFACTORY TREATMENT OPTIONS Phase I Principal Investigator Armstrong,…

201704120

A Phase II Randomized Controlled Trial of Neoadjuvant Pembrolizumab with Radiotherapy and Adjuvant Pembrolizumab in Patients with High-Risk, Localized Soft Tissue Sarcoma of the Extremity Phase II Principal Investigator Van Tine, Brian Disease Site Kaposi’s…

201705074

A Phase 2 Study of Anti-PD-L1 Antibody MPDL3280A (Atezolizumab) in Alveolar Soft Part Sarcoma Phase II Principal Investigator Van Tine, Brian Disease Site Soft Tissue Learn more about this study at: clinicaltrials.gov

201706123

ADVL1622 – Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors Phase II Principal Investigator Hayashi, Robert…

201709159

A Phase III Study of AL3818 (Catequentinib,Anlotinib) Hydrochloride Monotherapy in Subjects with Metastatic or Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma and Synovial Sarcoma Phase III Principal Investigator Van Tine, Brian Disease Site Sarcoma; Soft Tissue…

201801202

A Phase IB Trial Of Neoadjuvant AMG 232 Concurrent With Preoperative Radiotherapy In Wild-Type P53 Soft Tissue Sarcoma (STS) Phase I Principal Investigator Van Tine, Brian Disease Site Sarcoma; Soft Tissue Learn more about this…

201804011

A Phase 2 Trial of the MEK inhibitor selumetinib (AZD6244 hydrogen sulfate) in combination with the mTOR inhibitor sirolimus for patients with unresectable or metastatic malignant peripheral nerve sheath tumors Phase II Principal Investigator Van…

201804065

A Multi-center Phase III, Randomized, Open-Label Trial of Vigil (bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in combination with Irinotecan and Temozolimide as a Second-Line Regimen for Ewing’s Sarcoma

201810195

A Phase I/II Open-label, Multi-center Study of the Safety and Efficacy of IMCnyeso, an HLA- A*0201-Restricted, NY-ESO-1- and LAGE-1A-specific Soluble T Cell Receptor and Anti-CD3 Bispecific Molecule, as a Single Agent in HLA-A*0201 Positive Patients…

201901195

A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of DCC-2618 vs Sunitinib in Patients with Advanced Gastrointestinal Stromal Tumors after Treatment with Imatinib (intrigue) Phase III (Cancer Control) Principal Investigator Van Tine, Brian Disease Site…

201904042

Prehabilitation and Enhanced Recovery After Surgery to Improve Acute Wound Healing Complications in Soft Tissue Sarcoma Treated with Neoadjuvant Radiotherapy Phase N/A Principal Investigator Spraker, Matthew Disease Site Sarcoma; Soft Tissue Learn more about this…

201904069

Induction Paclitaxel followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma Phase II Principal Investigator Spraker, Matthew Disease Site Other Skin; Sarcoma; Soft Tissue Learn more about this study at: clinicaltrials.gov

201904212

A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR™ T cells in subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma (SPEARHEAD 1 STUDY) Phase II Principal Investigator Van Tine, Brian Disease Site…

201905131

A Phase 2b Trial of the MEK 1/2 Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients with Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) that are Progressing or Causing Significant Morbidity Phase II (Cancer…

201905136

Protocol J1S-MC-JAAA CAMPFIRE: Childrens and Young Adult Master Protocol for Innovative Pediatric Research Phase II Principal Investigator Van Tine, Brian Disease Site Sarcoma; Soft Tissue Learn more about this study at: clinicaltrials.gov

201906040

A PHASE 1b STUDY OF PTC596 IN COMBINATION WITH DACARBAZINE IN PATIENTS WITH LOCALLY RECURRENT, UNRESECTABLE OR METASTATIC RELAPSED/REFRACTORY LEIOMYOSARCOMA

201907126

Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered NY-ESO-1-Specific (c259) T Cells, alone or in combination with other agents, in HLA-A2+ Participants with NY-ESO-1 and/or LAGE-1a Positive Solid Tumors Phase II…

201911176

A Phase 1b/3 Global, Randomized, Double-blind, Placebo-Controlled Trial of Tazemetostat in Combination With Doxorubicin as Frontline Therapy for Advanced Epithelioid Sarcoma Phase III (Cancer Control) Principal Investigator Van Tine, Brian Disease Site Sarcoma; Soft Tissue…

201912062-1001

A Phase II Trial of ADI-PEG 20 in Combination with Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma, Osteosarcoma, Ewing’s Sarcoma, and Small Cell Lung Cancer Phase II Principal Investigator Van Tine, Brian…

202001168

A Phase 2, Single-Arm Open-Label Study of Abemaciclib for Treatment of Advanced Bone and Soft Tissue Sarcoma Identified as having CDK Pathway Alteration Phase II Principal Investigator Van Tine, Brian Disease Site Bones and Joints;…

202002113

A Phase II Study of Cabozantinib and Temozolomide in Patients with Unresectable or Metastatic Leiomyosarcoma and Other Soft Tissue Sarcomas

202003170

Master Protocol to Assess the Safety and Recommended Phase 2 Dose of Next Generations of Autologous Enhanced NY-ESO-1/ LAGE-1a TCR Engineered T-cells, alone or in combination with other agents, in Participants with Advanced Tumors Phase…

202006030

Phase 1, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Subjects with Advanced Gastrointestinal Stromal Tumor Phase I Principal Investigator Van Tine, Brian Disease Site Small Intestine; Soft Tissue; Stomach Learn more about this study at:…

202008172

Phase 2 Study of Belinostat and SGI-110 (Guadecitabine) for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma Phase II Principal Investigator Van Tine, Brian Disease Site Bones and Joints; Sarcoma Learn more about this study…

202009022

A Trial of Palliative Lattice Stereotactic Body Radiotherapy (SBRT) for Patients with Sarcoma, Thoracic, Abdominal, and Pelvic Cancers Phase N/A Principal Investigator Spraker, Matthew Disease Site Esophagus; Lung; Other Female Genital; Other Male Genital; Prostate;…

202010060

A MULTICENTER PHASE II TRIAL OF PACLITAXEL WITH AND WITHOUT NIVOLUMAB IN TAXANE NAÏVE,AND NIVOLUMAB AND CABOZANTINIB IN TAXANE PRETREATED SUBJECTS WITH ANGIOSARCOMA Phase II Principal Investigator Van Tine, Brian Disease Site Sarcoma; Soft Tissue…