Clinical Trials for Sarcoma

201510016

A Phase II Study of sEphB4-HSA in Kaposi Sarcoma Phase II Principal Investigator Ratner, Lee Disease Site Kaposi’s Sarcoma Learn more about this study at: clinicaltrials.gov

201601048

Phase 1 study evaluating combination therapy with the receptor tyrosine kinase inhibitor Turalio® (Pexidartinib (PLX3397) and Sirolimus in patients with unresectable sarcoma and Phase 2 study in malignant peripheral nerve sheath tumors. Phase I/II Principal…

201704120

A Phase II Randomized Controlled Trial of Neoadjuvant Pembrolizumab with Radiotherapy and Adjuvant Pembrolizumab in Patients with High-Risk, Localized Soft Tissue Sarcoma of the Extremity Phase II Principal Investigator Van Tine, Brian Disease Site Kaposi’s…

201709159

A Phase III Study of AL3818 (Catequentinib,Anlotinib) Hydrochloride Monotherapy in Subjects with Metastatic or Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma and Synovial Sarcoma Phase III Principal Investigator Van Tine, Brian Disease Site Bones and Joints;…

201801202

A Phase IB Trial Of Neoadjuvant AMG 232 Concurrent With Preoperative Radiotherapy In Wild-Type P53 Soft Tissue Sarcoma (STS) Phase I Principal Investigator Weiss, Mia Disease Site Soft Tissue Learn more about this study at:…

201904069

Induction Paclitaxel followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma Phase II Principal Investigator Spraker, Matthew Disease Site Other Skin Learn more about this study at: clinicaltrials.gov

201904129

A Randomized Study Comparing the Efficacy of the Combination of Doxorubicin and the Tumor-Targeting Human Antibody-Cytokine Fusion Protein L19TNF to Doxorubicin Alone as First-Line Therapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Phase…

201904212

A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR T cells in subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma (SPEARHEAD 1 STUDY) Phase II Principal Investigator Van Tine, Brian Disease Site…

201905136

Protocol J1S-MC-JAAA CAMPFIRE: Childrens and Young Adult Master Protocol for Innovative Pediatric Research Phase I/II Principal Investigator Van Tine, Brian Disease Site Soft Tissue Learn more about this study at: clinicaltrials.gov

201906040

A PHASE 1b STUDY OF PTC596 IN COMBINATION WITH DACARBAZINE IN PATIENTS WITH LOCALLY RECURRENT, UNRESECTABLE OR METASTATIC RELAPSED/REFRACTORY LEIOMYOSARCOMA Phase I Principal Investigator Van Tine, Brian Disease Site Soft Tissue Learn more about this…

201907126

Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered NY-ESO-1-Specific (c259) T Cells, alone or in combination with other agents, in HLA-A2+ Participants with NY-ESO-1 and/or LAGE-1a Positive Solid Tumors Phase II…

202001168

A Phase 2, Single-Arm Open-Label Study of Abemaciclib for Treatment of Advanced Bone and Soft Tissue Sarcoma Identified as having CDK Pathway Alteration Phase II Principal Investigator Weiss, Mia Disease Site Bones and Joints; Soft…

202002113

A Phase II Study of Cabozantinib and Temozolomide in Patients with Unresectable or Metastatic Leiomyosarcoma and Other Soft Tissue Sarcomas Phase II Principal Investigator Weiss, Mia Disease Site Soft Tissue Learn more about this study…

202003170

Master Protocol to Assess the Safety and Recommended Phase 2 Dose of Next Generations of Autologous Enhanced NY-ESO-1/ LAGE-1a TCR Engineered T-cells, alone or in combination with other agents, in Participants with Advanced Tumors Phase…

202008172

: NCI Protocol 10330, A Phase 2 Study of Belinostat and SGI-110 (Guadecitabine) or ASTX727 for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma Phase II Principal Investigator Weiss, Mia Disease Site Bones and Joints…

202009022

A Trial of Palliative Lattice Stereotactic Body Radiotherapy (SBRT) for Patients with Sarcoma, Thoracic, Abdominal, and Pelvic Cancers Phase N/A Principal Investigator Spraker, Matthew Disease Site Bones and Joints; Cervix; Colon; Corpus Uteri; Esophagus; Ill-Defined…

202010010

ENVASARC: A PIVOTAL TRIAL OF ENVAFOLIMAB, AND ENVAFOLIMAB IN COMBINATION WITH IPILIMUMAB, IN PATIENTS WITH ADVANCED OR METASTATIC UNDIFFERENTIATED PLEOMORPHIC SARCOMA OR MYXOFIBROSARCOMA WHO HAVE PROGRESSED ON PRIOR CHEMOTHERAPY Phase II (Cancer Control) Principal Investigator…

202010060

A MULTICENTER PHASE II TRIAL OF PACLITAXEL WITH AND WITHOUT NIVOLUMAB IN TAXANE NAÏVE,AND NIVOLUMAB AND CABOZANTINIB IN TAXANE PRETREATED SUBJECTS WITH ANGIOSARCOMA Phase II Principal Investigator Van Tine, Brian Disease Site Soft Tissue Learn…

202010122

A Phase 2 Study of Anti-PD-L1 Antibody (Atezolizumab) in Chondrosarcoma and Clear Cell Sarcoma Phase II Principal Investigator Van Tine, Brian Disease Site Bones and Joints; Soft Tissue Learn more about this study at: clinicaltrials.gov

202011041

A Randomized Phase II Trial of Cabozantinib Combined with PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma Phase II Principal Investigator Van Tine, Brian Disease Site Soft Tissue Learn more about this study at:…

202012066

A PHASE Ib /II STUDY OF APG-115 IN COMBINATION WITH PEMBROLIZUMAB IN PATIENTS WITH UNRESECTABLE OR METASTATIC MELANOMAS OR ADVANCED SOLID TUMORS Phase I/II Principal Investigator Van Tine, Brian Disease Site Anus; Bones and Joints;…

202101200

Phase 1, first-in-human, open-label dose escalation and cohort expansion study of KB-0742 in patients with relapsed or refractory solid tumors or non-Hodgkin lymphoma Phase I (Cancer Control) Principal Investigator Van Tine, Brian Disease Site Anus;…

202102173

A Multicenter Phase 1, Open-Label Study of SQ3370 in Patients with Advanced Solid Tumors Phase I Principal Investigator Weiss, Mia Disease Site Breast; Corpus Uteri; Non-Hodgkin Lymphoma; Ovary; Soft Tissue; Urinary Bladder Learn more about…

202103092

A Phase 2 Study of Talimogene Laherparepvec (T-VEC) and Radiation in Localized Soft Tissue Sarcoma Phase II Principal Investigator Weiss, Mia Disease Site Soft Tissue Learn more about this study at: clinicaltrials.gov

202105158

A Phase 1 Open-label, Multicenter, Dose-ranging Study to Investigate Safety and Tolerability, Efficacy, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of MT-6402 in Subjects with Advanced Solid Cancer That Expresses PD-L1 Phase I (Cancer Control) Principal Investigator Van…

202106131

Multicenter Phase II Study of Pomalidomide Monotherapy in Kaposi Sarcoma Phase II Principal Investigator Ratner, Lee Disease Site Kaposi’s Sarcoma Learn more about this study at: clinicaltrials.gov

202107082

A phase II trial with a safety lead-in to evaluate the addition of APX005M, a CD40 agonistic monoclonal antibody, to standard-of-care doxorubicin for the treatment of advanced sarcoma Phase II Principal Investigator Weiss, Mia Disease…

202107168

Phase 1 trial of the LSD1 Inhibitor Seclidenstat (SP-2577) with and without Topotecan and Cyclophosphamide in patients with relasped or refractory Ewing Sarcoma and select Sarcomas Phase I Principal Investigator Van Tine, Brian Disease Site…

202108106

A Randomized Multicenter Phase 3 Study of Milademetan Versus Trabectedin in Patients with Dedifferentiated Liposarcoma Phase III (Cancer Control) Principal Investigator Weiss, Mia Disease Site Soft Tissue Learn more about this study at: clinicaltrials.gov

202108161

SARC041: Phase 3 Randomized Double-Blind Study of Abemaciclib versus Placebo in Patients with Advanced Dedifferentiated Liposarcoma Phase III (Cancer Control) Principal Investigator Weiss, Mia Disease Site Soft Tissue Learn more about this study at: clinicaltrials.gov

202112086

A dose escalation and dose expansion study of NOX66 plus doxorubicin in anthracycline-naïve, adult patients with soft tissue sarcoma – CEP-2 Phase I (Cancer Control) Principal Investigator Weiss, Mia Disease Site Soft Tissue Learn more…

202202093

A Phase 1/2 Open-Label, Multicenter Study to Characterize the Safety and Tolerability of CFT8634 in Subjects With Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors Phase I/II (Cancer Control) Principal Investigator…