Clinical Trials

201410102

Positron emission tomography (PET) imaging of poly(ADP-ribose) polymerase (PARP) activity in cancer Phase Early Phase I Principal Investigator Dehdashti, Farrokh Disease Site Colon; Lip, Oral Cavity and Pharynx; Liver; No Disease; Pancreas; Rectum; Unknown Sites…

201704082

Ramucirumab plus irinotecan in patients with previously treated advanced gastric or gastro-esophageal junction adenocarcinoma Phase II Principal Investigator Park, Haeseong Disease Site Esophagus; Stomach Learn more about this study at: clinicaltrials.gov

201705166

Intravenous lidocaine for preventing painful oxaliplatin-induced peripheral neuropathy (OIPN) Phase I/II Principal Investigator Haroutounian, Simon Disease Site Colon; Rectum Learn more about this study at: clinicaltrials.gov

201708029

A Multi-Institutional Phase 2 Study of Nivolumab in Refractory Metastatic Squamous Cell Carcinoma of the Anal Canal Phase II Principal Investigator Amin, Manik Disease Site Anus Learn more about this study at: clinicaltrials.gov

201709013

A Multicenter Pilot Study of Nivolumab with Drug Eluting Bead Transarterial Chemoembolization in Patients with Advanced Hepatocellular Carcinoma Phase Early Phase I Principal Investigator Tan, Benjamin Disease Site Liver Learn more about this study at:…

201710148

A Multi-Center, Open-Label, Phase 1/1b Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anticancer Activity of Fruquintinib in Patients with Advanced Solid Tumors Phase I Principal Investigator Amin, Manik Disease Site Anus; Brain and…

201710206

Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair Phase III Principal Investigator Pedersen, Katrina Disease Site Colon Learn…

201712097

A Randomized Phase II Study of Trastuzumab and Pertuzumab (TP) Compared to Cetuximab and Irinotecan (Cetiri) in Advanced/Metastatic Colorectal Cancer (MCRC) with Her-2 Applification Phase II Principal Investigator Tan, Benjamin Disease Site Colon; Rectum Learn…

201803092

A Phase II Study of Proton Beam Therapy in the Treatment of Esophageal Cancer Phase II Principal Investigator Badiyan, Shahed Disease Site Esophagus Learn more about this study at: clinicaltrials.gov

201805016

A Phase II Multi-Center Study of SM-88 in Subjects with Pancreatic Cancer Whose Disease Has Progressed or Recurred after/on First Line Chemotherapy Phase II/III Principal Investigator Tan, Benjamin Disease Site Pancreas Learn more about this…

201805117

A Phase Ib/II Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-based Treatment Combinations in Patients with Metastatic Colorectal Cancer (MORPHEUS-CRC)

201805157

A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer Phase II Principal Investigator Amin, Manik Disease Site Anus Learn more about this study at: clinicaltrials.gov

201806007

A phase I/II study to evaluate the tolerability and efficacy of BMS-813160 (CCR2/5 inhibitor) with nivolumab and gemcitabine and nab-paclitaxel in borderline resectable and locally advanced pancreatic ductal adenocarcinoma (PDAC) Phase I/II Principal Investigator Lim,…

201806046

A Phase 3, Randomized, Double-blind Study of Adjuvant Nivolumab versus Placebo for Participants with Hepatocellular Carcinoma Who Are at High Risk of Recurrence after Curative Hepatic Resection or Ablation (CheckMate 9DX: CHECKpoint pathway and nivoluMAb…

201807070

A Phase 1/2, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 510 Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and AMG 510 Combination Therapy in Subjects With…

201807099

Novel CCR2 PET for Pancreatic Cancer Imaging and Prediction of Response to Standard and CCR2-Targeted Therapy Phase I Principal Investigator Dehdashti, Farrokh Disease Site Pancreas Learn more about this study at: clinicaltrials.gov

201808116

A Phase III, Randomized, Double-blind Trial Comparing Trastuzumab Plus Chemotherapy and Pembrolizumab With Trastuzumab Plus Chemotherapy and Placebo as First-line Treatment in Participants With HER2 Positive Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (KEYNOTE 811)

201808122

Randomized, Double-blinded Phase III Study of Cabozantinib versus Placebo in Patients with Advanced Neuroendocrine Tumors after Progression on Everolimus Phase III Principal Investigator Trikalinos, Nikolaos Disease Site Lung; Pancreas Learn more about this study at:…

201808178

A Phase II study of chemotherapy and immune checkpoint blockade with Pembrolizumab in the perioperative and maintenance treatment of locoregional gastric or GE junction adenocarcinoma. Phase II (Cancer Control) Principal Investigator Park, Haeseong Disease Site…

201811130

A Phase 1, Open-Label, Dose Escalation Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy Study of Topically Administered LUT014 in Metastatic Colorectal Cancer Patients with EGFR Inhibitor Induced Acneiform Lesions Phase I (Cancer Control) Principal Investigator Anadkat,…

201812139

Prospective phase II Study of Stereotactic MR-guided on-table Adaptive Radiation Therapy (SMART) for Patients with Borderline or Inoperable Locally Advanced Pancreatic Cancer Phase II Principal Investigator Kim, Hyun Disease Site Pancreas Learn more about this…

201901172

Pilot Study of Same-session MR-only Simulation and Treatment with MRI-guided Adaptive Palliative Radiotherapy Phase N/A Principal Investigator Kim, Hyun Disease Site Anus; Bones and Joints; Brain and Nervous System; Breast; Cervix; Colon; Corpus Uteri; Esophagus;…

201901195

A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of DCC-2618 vs Sunitinib in Patients with Advanced Gastrointestinal Stromal Tumors after Treatment with Imatinib (intrigue) Phase III (Cancer Control) Principal Investigator Van Tine, Brian Disease Site…

201902040

Phase I study of epacadostat (INCB024360) added to preoperative chemoradiation in patients with locally advanced rectal cancer Phase I Principal Investigator Park, Haeseong Disease Site Rectum Learn more about this study at: clinicaltrials.gov

201902131

A PHASE III RANDOMIZED TRIAL OF GEMCITABINE, CISPLATIN, AND NAB-PACLITAXEL VERSUS GEMCITABINE AND CISPLATIN IN NEWLY DIAGNOSED, ADVANCED BILIARY TRACT CANCERS Phase III Principal Investigator Amin, Manik Disease Site Other Digestive Organ Learn more about…

201903120

A Phase I Open Label, Clinical Trial Evaluating the Safety and Anti-tumor Activity of Autologous T Cells Expressing Enhanced TCRs Specific for Alpha-fetoprotein (AFPc332T) in HLA-A2 Positive Subjects with Advanced Hepatocellular Carcinoma (HCC) or Other…

201903188

Phase III placebo-controlled trial to evaluate dexamethasone use for everolimus-induced oral stomatitis: prevention versus early treatment approaches Phase III Principal Investigator Trikalinos, Nikolaos Disease Site Anus; Colon; Esophagus; Liver; Other Digestive Organ; Pancreas; Rectum; Small…

201904029

Non-Operative Management and Early Response Assessment in Rectal Cancer (NOM-ERA) Phase II Principal Investigator Kim, Hyun Disease Site Rectum Learn more about this study at: clinicaltrials.gov

201905167

A Phase III Randomized, Double-Blind, Placebo-Controlled, Multi- Regional, International Study of Durvalumab in Combination with Gemcitabine plus Cisplatin versus Placebo in Combination with Gemcitabine plus Cisplatin for Patients with First-Line Advanced Biliary Tract Cancers (TOPAZ-1)

201905170

A Phase 2, multicenter open-label, non-randomized study of bavituximab plus pembrolizumab in patients with advanced gastric or gastroesophageal cancer who have progressed on or after at least one prior standard therapy Phase II Principal Investigator…

201905201

A pilot study of liposomal irinotecan plus 5-FU / LV combined with paricalcitol in patients with advanced pancreatic cancer progressed on gemcitabine-based therapy

201906106

Debio 1143 a SMAC Mimetic in Combination with Nivolumab in Patients Failing Prior PD 1/PD-L1 Treatment: A Basket Trial Phase I/II (Cancer Control) Principal Investigator Morgensztern, Daniel Disease Site Cervix; Colon; Corpus Uteri; Esophagus; Lip,…

201906169

Phase 1b/2 Open-label Study to Evaluate the Safety, Tolerability and Efficacy of Rivoceranib or Trifluridine/Tipiracil as Monotherapies and Rivoceranib and Trifluridine/Tipiracil as Combination Therapy in Subjects with Metastatic Colorectal Cancer Phase I/II Principal Investigator Trikalinos,…

201907095

A Phase 1/2, First-in-Human, Open-label, Dose Escalation Study of GB1275 Monotherapy and in Combination with an Anti-PD-1 Antibody in Patients with Specified Advanced Solid Tumors or in Combination with Standard of Care in Patients with…

201908005

The role of multimodality management in risk-stratified patients with lung-limited metastatic colorectal cancer Phase II Principal Investigator Kozower, Benjamin Disease Site Colon; Lung; Metastatic Disease; Rectum Learn more about this study at: clinicaltrials.gov

201908124

A Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of a Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy Phase I Principal Investigator Gillanders, William Disease Site…

201908202

A Phase 2/3 Trial to Evaluate Margetuximab in Combination with INCMGA00012 and Chemotherapy or MGD013 and Chemotherapy in Patients with Metastatic or Locally Advanced, Treatment-naïve, HER2-Positive Gastric or Gastroesophageal Junction Cancer Phase II/III Principal Investigator…

201909019

Phase I Study of Radiation Dose Intensification with Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Concurrent Carboplatin and Paclitaxel for Inoperable Esophageal Cancer Phase I Principal Investigator Badiyan, Shahed Disease Site Esophagus Learn more about…

201909063

A Phase I, First-In-Human, Multicenter, Open-Label Study of Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors Phase I Principal Investigator Pedersen, Katrina Disease Site Other Learn more about this study at: clinicaltrials.gov

201909077

A Phase 3 Randomized, Open-label Study to Evaluate the Efficacy and Safety of Olaparib Alone or in Combination With Bevacizumab Compared to Bevacizumab With 5-FU in Participants with Unresectable or Metastatic Colorectal Cancer who Have…

201909083

A Phase I A/B Study to Evaluate the Safety and Tolerability of ETC-1922159 in Advanced Solid Tumours Phase I (Cancer Control) Principal Investigator Devarakonda, Siddhartha Disease Site Anus; Breast; Colon; Esophagus; Kidney; Liver; Lung; Lung…

201910170

A Phase 1b, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects with Advanced Solid Tumors With KRAS p.G12C Mutation Phase I Principal Investigator Govindan, Ramaswamy Disease Site Breast; Esophagus;…

201911054

Phase II Study of Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Previously Treated Advanced Biliary Tract Cancer (NAPOLI-2) Phase II Principal Investigator Pedersen, Katrina Disease Site Other Learn more about this study at: clinicaltrials.gov

201911059

Preoperative MR-Guided Radiation Therapy to Improve Oncologic Outcomes in Gastric Cancer Phase N/A Principal Investigator Kim, Hyun Disease Site Stomach Learn more about this study at: clinicaltrials.gov

201911080

A Phase II Study to Evaluate the Safety and Efficacy of OQL011 on VEGFR Inhibitor-Associated Hand-foot Skin Reaction in Cancer Patients Study Number OQL011B002 Phase II Principal Investigator Anadkat, Milan Disease Site Acute Myeloid Leukemia…

201911155

A Phase 1 Study to Evaluate the Safety and Tolerability of AB680 Combination Therapy in Participants with Gastrointestinal Malignancies Phase I (Cancer Control) Principal Investigator Lim, Kian-Huat Disease Site Metastatic Disease; Pancreas Learn more about…

201911159

PRECISION PROMISE PLATFORM TRIAL FOR METASTATIC PANCREATIC CANCER Phase III (Cancer Control) Principal Investigator Lim, Kian-Huat Disease Site Other Learn more about this study at: clinicaltrials.gov

201912015

A Phase 1/2a Open-label, Multicenter, Dose Escalation and Dose Expansion Study of the Safety, Tolerability, and Pharmacokinetics of HPN536 in Patients with Advanced Cancers Associated with Mesothelin Expression Who Have Failed Standard Available Therapy Phase…

201912087

A phase 2, open-label, single-arm trial of trastuzumab deruxtecan (ds-8201a) in her2- positive, unresectable or metastatic gastric or gastro-esophageal junction (GEJ) adenocarcinoma subjects who have progressed on or after a trastuzumabcontaining regimen Phase II (Cancer…

201912097

A Phase 1 Open Label, Multi-Arm, Multicenter Study of MK-4830 as Monotherapy and in Combination with Pembrolizumab for Participants with Advanced Solid Tumors Phase I Principal Investigator Adkins, Douglas Disease Site Kidney; Larynx; Lip, Oral…

201912123

RANDOMIZED DOUBLE-BLIND PHASE III TRIAL OF VITAMIN D3 SUPPLEMENTATION IN PATIENTS WITH PREVIOUSLY UNTREATED METASTATIC COLORECTAL CANCER (SOLARIS) Phase III Principal Investigator Pedersen, Katrina Disease Site Colon; Metastatic Disease; Rectum Learn more about this study…

202001128

A phase I/Ib, open-label, multi-center, study of KAZ954 as a single agent and in combination with Spartalizumab, NZV930 and NIR178 in patients with advanced solid tumors Phase Early Phase I (Cancer Control) Principal Investigator Park,…

202001226

Randomized Phase II Selection Study of Ramucirumab and Paclitaxel versus FOLFIRI in Refractory Small Bowel Adenocarcinoma Phase II Principal Investigator Pedersen, Katrina Disease Site Small Intestine Learn more about this study at: clinicaltrials.gov

202002190

A Phase III Study of Consolidative Radiotherapy in Patients with Oligometastatic HER2 Negative Esophageal and Gastric Adenocarcinoma (EGA) Phase III Principal Investigator Park, Haeseong Disease Site Esophagus; Metastatic Disease; Stomach Learn more about this study…

202003005

A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) EA2182 Phase II Principal Investigator Henke, Lauren Disease Site Anus Learn more about this study at: clinicaltrials.gov

202003057

Phase II/III Study of Circulating tumOr DNA as a Predictive BiomaRker in Adjuvant Chemotherapy in Patients with Stage IIA Colon Cancer (COBRA) Phase II/III Principal Investigator Pedersen, Katrina Disease Site Colon Learn more about this…

202003096

A Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation Phase I/II (Cancer Control) Principal Investigator Park, Haeseong Disease Site Colon; Corpus Uteri; Lung; Ovary;…

202005073

A Phase 1 Multicenter Global First in Human Study of the CD73 Inhibitor LY3475070 as Monotherapy or in Combination with Pembrolizumab in Patients with Advanced Solid Malignancies Phase I Principal Investigator Opyrchal, Mateusz Disease Site…

202006156

A Phase 2b, open-label, single-arm study of ZW25 monotherapy in subjects with advanced or metastatic HER2-amplified biliary tract cancers Phase II Principal Investigator Tan, Benjamin Disease Site Other Digestive Organ Learn more about this study…

202007217

A MULTI-CENTER, OPEN-LABEL, PHASE 2 STUDY TO EVALUATE SAFETY AND EFFICACY OF U3-1402 IN SUBJECTS WITH ADVANCED OR METASTATIC COLORECTAL CANCER (CRC) Phase II Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about…