About Pediatric Brain Tumors

What are pediatric brain tumors? Are there different kinds?

A brain tumor is an abnormal growth of cells found in the central nervous system, either in the brain or the spinal cord. Pediatric brain tumors are the most common solid tumor in children, and there are many different kinds. Every brain tumor falls into one of two categories: benign and malignant. They can happen at any age and are very different from brain tumors in adults.  

Benign brain tumors are not cancerous, but because they are in the brain and can impact different functions of the body as they grow, they always require intervention. Sometimes, if a benign brain tumor is removed, it will not grow back. In our patients, more than half cannot have their tumor completely removed with surgery, so it is typical for patients to receive chemotherapy or targeted therapy, or, in some cases, radiation therapy. 

Malignant brain tumors have cancer cells. These cells can grow quickly and can spread within the brain or in the spinal cord. Cancerous, or malignant, brain tumors do not often spread beyond the brain or spinal cord. It is possible that the tumor may grow back after treatment.  

Pediatric brain tumors can grow anywhere in the brain, including the cerebrum, cerebellum, and brainstem, and where the tumor is located will help your child’s physician decide how to treat it. The treatment that children need is often quite different from adult brain tumors, so it is important to receive care with a team that is experienced in the management of pediatric brain tumors. All children with malignant brain tumors will have a treatment plan that combines surgery with chemotherapy or radiotherapy. 

Siteman Kids’ Pediatric Brain Tumor Program experts collaborate with The Brain Tumor Center at Siteman. WashU Medicine physicians from both groups participate in tumor boards to consider new approaches and establish the best, unique treatment plans for patients. 

See pediatric tumor types:

The most common type of pediatric brain tumors are gliomas. Gliomas begin as glial cells, which are cells that create supportive tissue in the brain. There are different types of gliomas, and they grow in different areas of the brain.  

  • Pediatric-type diffuse low-grade gliomas 
  • Pediatric-type diffuse high-grade gliomas 
  • Circumscribed astrocytic gliomas, including diffuse midline glioma 
  • Ependymoma 
  • Oligodendroglioma  
  • Optic nerve glioma 

Other types of brain tumors include: 

  • Medulloblastoma  
  • Other embryonal tumors   
  • Choroid plexus tumor 
  • Craniopharyngioma 
  • Mixed glial and neuronal tumors  
  • Schwannoma 
  • Germ cell tumors 
  • Atypical teratoid rhabdoid tumors 

What are the early symptoms of a pediatric brain tumor?

Some early symptoms of pediatric tumors can seem like other, more common illnesses and are easy to ignore, while others are concerning and cause parents to take their child to the doctor or emergency room. It is important to seek medical advice if neurological symptoms come on quickly and severely.  

Some common early symptoms of pediatric brain tumors include: 
  • Headache 
  • Nausea and vomiting 
  • Personality and mood changes 
  • Drowsiness 
  • Seizures 
  • Coma 
  • Changes in eyesight (including double vision) or hearing (including hearing loss) 
  • Trouble talking or swallowing 
  • Weakness or paralysis 
  • Trouble with eye movement 
  • Clumsy movements of the hands, arms, feet, or legs 
  • Problems walking (ataxia) 
  • Muscle stiffness 

Because their skulls are not fully formed, babies and infants’ symptoms can differ from older children’s. One notable symptom of brain tumors in babies is an enlarged, swollen head. Although this symptom can be caused by other, benign conditions, you should still make an appointment with your pediatrician if you observe it in your infant.  

How are brain tumors diagnosed in children? 

There are several tests a physician can do to determine if your child has a brain tumor. Some of these will be tests they have done before, like a blood test, and others will be new. If they suspect there is a brain tumor, the physician will first do tests that check your child’s nervous system. They can do this right in the exam room by talking with your child, checking their reflexes, conducting an eye exam, assessing their overall coordination, and more. If you are at your pediatrician, they may refer you to a neurologist.  

 Some tests that your physician may order include: 
  • CT scan. A CT scan uses a series of X-rays and a computer to make detailed pictures of the body. 
  • MRI. An MRI uses large magnets, radio waves, and a computer to make detailed pictures of the body. Contrast dye may be injected into your child’s vein. It helps cancer cells be seen more clearly. 
  • Lumbar puncture. A special needle is placed into the lower back, into the spinal canal, to take a small amount of cerebral spinal fluid (CSF) to check it for cancer cells.  
  • Biopsy. To learn exactly what cells are in a tumor, some of the cells are removed and sent to a lab for testing. This is done to determine the type of tumor and how fast it is likely to grow. 
  • Blood tests. Blood tests may be done to check for substances that are released by some tumors. These are called tumor markers. 

Can I ask for a second opinion about my child’s diagnosis? 

Our experts collaborate with other institutions that are seeking their input, and they request second opinions of colleagues at peer institutions as well. You can always request a second opinion when researching how to get your child the best pediatric cancer care. It is your right, and it is a common practice; many programs and hospitals encourage it. Siteman Kids at St. Louis Children’s Hospital makes requesting a second opinion easy. It is important that you feel confident about the care your child is getting and how their treatment is working. If you are getting care elsewhere and are interested in a second opinion from Siteman Kids at St. Louis Children’s Hospital, request it here

Why do families choose Siteman Kids for treating pediatric brain tumors?

Whenever a child has a brain tumor, they need care provided by a multi-disciplinary team that includes experts from neuro-oncology, neurosurgery, radiation oncology, neurology, neuropathology, neuroradiology, rehabilitation medicine, ophthalmology, endocrinology, and others. Siteman Kids at St. Louis Children’s Hospital includes all these expertise and offers cutting-edge care with a focus on not just your child, but on your family as well. Families at Siteman Kids are seen by WashU Medicine physicians who have specialized in pediatric medicine and are working on clinical trials and research studies to unlock new treatments for curing disease. U.S. News and World Report ranks us #12 in the nation for neurosurgery and neurology programs and as one of the nation’s top children’s hospitals. We are the only children’s hospital in Missouri that receives funding from the National Cancer Institute for ongoing research.  

In addition to providing the best pediatric cancer care in the St. Louis region, Siteman Kids pediatric brain tumor program is a member of:

all international organizations of experts conducting research on brain tumors. Siteman Kids is the only member of PNOC in the region, attracting not just families from the area but also drawing patients from across the globe to be a part of the clinical trials offered.  

At Siteman Kids we care for the whole family. Our support services are extensive, providing professionals who care for the well-being of our young patients, their siblings and their caregivers. Psychologists guide children and their families through the many emotions that come from a cancer diagnosis with in-person and virtual visits. Child Life specialists assist in practical ways, educating your child on what procedures will be like, helping them learn coping strategies for their fears and stress and more. Educational liaisons help communicate and coordinate with your school district so there is a plan for continuing to learn, even when being in the classroom isn’t possible. And families receive the comprehensive support of social workers who can guide adults through the many responsibilities and realities related to caretaking while balancing work and parenting.   

Click here to read more about Siteman Kids’ family services and resources. 

Request an Appointment

Call our nurse navigators to begin setting up an appointment for your child. They are able to answer questions and guide you to resources.