About Pediatric Solid Tumors

What are pediatric solid tumors? Are there different kinds?

A tumor is a term that describes a group of cells, or mass, that is not normally found in blood cells. A “solid” tumor is a way to describe the abnormal group of cells that make it up. Most cells that form a solid tumor are all the same type, without any cysts, liquids, or other kinds of cells inside of it.  

There are many kinds of solid tumors and they can be grouped into two categories: malignant or benign. If the cells can spread, a tumor is considered cancerous, or malignant, and if the cells can’t spread, those tumors are called “benign.”  

Solid tumors in children are rare, and they can develop in many different parts of the body. Identifying if a child has a solid tumor, if it is malignant or benign, and testing to see what kind of tumor cells are present are all important steps in the diagnostic process.  

 

What kinds of solid tumors do children develop?

There are many different kinds of solid tumors that children can develop throughout the body. Most pediatric solid tumors are rare, with only a few cases in the U.S. each year. These young patients need a multidisciplinary approach to diagnose and treat them; our expertise is why so many families bring their child to Siteman Kids. 

Siteman Kids’ experts treat every kind of solid tumor, including:

Bone Sarcoma

 

Inflammatory Myofibroblastic Tumors/Myofibromatosis
  • Adrenocortical carcinoma 
  • Paraganglioma 
  • Pheochromocytoma 
Liver Tumors

There are a few pediatric solid tumors that grow in or on the liver. All are rare in children. Through diagnostic testing, physicians can determine what kind of tumor is present and recommend specialized treatment. 

  • Hepatoblastoma 
  • Hepatocellular carcinoma 
  • Hepatocellular neoplasm NOS 
  • Mesenchymal hamartomas 
Ovarian and Testicular Tumors
  • Germ Cell tumors 
  • Dysgerminomas 
  • Teratoma 
  • Testicular seminoma 
  • Sex cord stromal tumor (juvenile granulosa cell tumor, Sertoli-Leydig cell tumor) 
Melanoma

Skin cancers that develop in children are not like skin cancers found in adults. These cancers in kids can appear anywhere on the skin are not caused by sun exposure. Sometimes a child’s birthmark predisposes them to develop a form of skin cancer. Certain skin cancers can develop in a wide age range of children and may appear in preteens and teenagers. 

Neuroblastoma
  • Low and intermediate risk neuroblastoma 
  • High-risk neuroblastoma 
  • Neurogenic tumors such as ganglioneuroma 
Neurofibromatosis Type 1-related Tumors
  • Plexiform Neurofibromas 
  • Malignant peripheral nerve sheath tumor 
Rare Tumors
  • Nasopharyngeal carcinoma 
  • Pleuropulmonary blastoma 
Renal Tumors
  • Clear cell sarcoma of the kidney 
  • Congenital Mesoblastic Nephroma 
  • Renal cell carcinoma 
  • Renal medullary carcinoma 
  • Renal angiomyolipoma 
  • Rhabdoid tumor 
  • Wilms tumor 
Retinoblastoma

Retinoblastoma is a rare tumor that grows in the eye. It impacts the retina, which is located in the back of the eye.

Soft Tissue Sarcoma

A sarcoma is a solid tumor that grows within soft tissues in a child’s body – like muscles, tendons and connective tissue – or within their bones. Because bones and soft tissues are found within the entire body, sarcomas can grow anywhere and are able to spread. Most often children develop three kinds of sarcomas but our team of experts are experienced treating many more rare kinds of sarcoma. Some include: 

  • Desmoid tumors 
  • Infantile fibrosarcoma 
  • Non-rhabdomyosarcoma soft tissue sarcoma (synovial sarcoma, alveolar soft part sarcoma, desmoplastic small round cell tumor) 
  • Rhabdomyosarcoma 
Thyroid Cancer (Thyroid Carcinoma)

Thyroid cancer in children and young adults can sometimes be felt or seen as a lump in front of the neck on the thyroid gland or in the nearby lymph nodes. Thyroid cancer, also called thyroid carcinoma, can spread to the lymph nodes or beyond, sometimes into the lungs. There are a few different types of thyroid carcinoma that children develop, some of which are more common in adults. Siteman Kids experts have experience treating each of these thyroid cancers with a number of techniques including radiation, surgery and more. 

  • Anaplastic thyroid cancer 
  • Follicular thyroid carcinoma 
  • Medulary thyroid carcinoma 
  • Papillary thyroid carcinoma 

 

Is a brain tumor a kind of solid tumor? 

Yes, a pediatric brain tumor is considered a kind of solid tumor. But because brain tumors are one of the most common kinds of pediatric cancer, and because treating them requires a neuro-oncologist, they are often discussed as a separate kind of cancer. If your child has a brain tumor diagnosis, and you would like to learn more about the specialized care Siteman Kids offers them, click here.  

What causes solid tumors in children?

Hearing your child has a solid tumor is scary and brings up a lot of questions, including how this happened. Right now, the answer isn’t simple. For the most part, the cause or causes of solid tumors that children develop are unknown, and physician-scientists are researching why they grow. The most common and consistent risk factors are not preventable. These include inheriting certain genes that have a slight defect or having a syndrome such as Li-Fraumeni syndrome. But having an increased genetic risk, or even a syndrome doesn’t mean a child will develop cancer, and if there is a genetic risk, Siteman Kids can support your family through testing and counseling.  

What are the early symptoms of a pediatric tumor?

The symptoms a child with a pediatric solid tumor may experience will depend on many different factors, like the tumor’s location, the type of cells it contains, and its size. The symptoms of Ewing sarcoma may not be the same as the symptoms of a Wilms tumor.

While solid tumor symptoms and their severity can vary, and some need immediate medical care.

Seek medical care if your child is experiencing:  
  • Abdominal pain  
  • A visible lump 
  • Nausea and vomiting  
  • Fever  
  • Trouble with bowel movements (constipation)  
  • Blood in urine 
  • Coughing, chest pain or trouble breathing (dyspnea) 
  • Painless swelling of the lymph nodes in the neck, chest, abdomen, underarm, or groin  
  • Sore throat  
  • Bone and joint pain  
  • A broken bone without known trauma 
  • Night sweats  
  • Tiring easily (fatigue)  
  • Weight loss and/or poor appetite  
  • Recurring infections  

Many of the symptoms of pediatric cancers, including solid tumors, are similar to other common illnesses. Not all pediatric solid tumors have symptoms even when they’ve grown very large, so parents should see their pediatrician if they suspect their child is sick, especially if their child has been sick for more than a week. It’s also important to take your child for regular check-ups so the pediatrician can make sure they are growing and developing appropriately.  

How are solid tumors diagnosed in children?

There are several tests a physician can do to determine if your child has a solid tumor. Some of these will be tests your child has done before, like a blood test, and others will be new.  

Some tests that your physician may order include:
  • Blood tests. Blood tests may be done to check for substances that are released by some tumors. These are called tumor markers.  
  • Bone scan. A small amount of radioactive dye is injected into a vein. The whole body is scanned. The dye shows up in areas of bone where there may be cancer 
  • CT scan. A CT scan uses a series of X-rays and a computer to make detailed pictures of the body.   
  • MRI. An MRI uses large magnets, radio waves, and a computer to make detailed pictures of the body. Contrast dye may be injected into your child’s vein. It helps cancer cells be seen more clearly. 
  • Positron emission tomography (PET) scan. For this test, radioactive sugar is injected into the bloodstream for cancer cells to take in. A PET scan can show cancer cells in different areas of the body and is often used in combination with a CT scan. This is called a PET/CT scan. 
  • Tumor biopsy. To learn exactly what kind of cells are in a tumor, some of the cells are removed, or biopsied, and sent to a lab for testing. This is done to determine the type of tumor, how quickly it is likely to grow and if it is capable of spreading. 
  • Ultrasound. In an ultrasound, sound waves and a computer are used to create images. An ultrasound may be done to check different areas in your child’s body like the abdomen, eyes, or kidneys. Sometimes an ultrasound is used to guide a needle during a biopsy. 
  • X-rays. X-rays may be done to check your child’s chest or bones to see how dense they are and if any other growths have formed along them. 

It is important to note that your child’s well-being is a priority during diagnostic testing. Our care team tries to ease any fears or pain a patient has during testing. If needed, we can use light sedation to limit stress and help children feel more comfortable for more involved procedures.    

Can I ask for a second opinion about my child’s diagnosis? 

You can always request a second opinion when researching how to get your child the best pediatric cancer care. It is your right, and it is a common practice; many programs and hospitals encourage it. Siteman Kids at St. Louis Children’s Hospital makes requesting a second opinion easy. It is important that you feel confident about the care your child is getting and how their treatment is working. If you are interested in a second opinion from Siteman Kids at St. Louis Children’s Hospital, request it here.   

Why do families choose Siteman Kids for treating pediatric solid tumors?

After getting a correct diagnosis, the most important thing a parent or caregiver can do for their child is find the best care possible for them. Siteman Kids at St. Louis Children’s Hospital’s cutting-edge care stands out to families as they research pediatric oncology programs.  

Families choose Siteman Kids for our:
  • Experienced Care Teams. Siteman Kids at St. Louis Children’s Hospital brings expertise to children’s bedsides with oncology specialists, nurses, therapists, Child Life specialists, and support services so that your child’s learning, growth, and development are all important aspects of the treatment plan.  
  • Multidisciplinary Collaboration. When children are treated for cancer, they may need pediatric specialists added to their oncology team. Pediatric surgeons, cardiologists, neurologists, and orthopedists from St. Louis Children’s Hospital can be added seamlessly to existing multidisciplinary care teams.  
  • Research and Discoveries. Our physicians are often leading research in pediatric cancer as they work with young patients in the clinic, bringing innovation and breakthroughs to bedsides.  
  • Clinical Trials Access. Kids with cancer are often encouraged to participate in clinical trials. Because of their commitment to research, Siteman Kids is a site for many nationwide clinical trials and leads its own clinical trial research. This means eligible patients at Siteman Kids and their families won’t need to travel to enroll if they are eligible to participate. Click here to learn about the clinical trials Siteman Kids offers. [add link] 

Siteman Kids focuses on not just your child, but on your family as well. Families at Siteman Kids are seen by WashU Medicine physicians who have specialized in pediatric medicine and are working on clinical trials and research studies to unlock new treatments for curing disease. U.S. News and World Report consistently ranks St. Louis Children’s Hospital as one of the top children’s hospitals in the country. We are the only children’s hospital in Missouri that receives funding from the National Cancer Institute for ongoing research. 

Additionally, Siteman Kids’ support services are extensive, providing professionals who care for the well-being of our young patients, their siblings and their caregivers. Psychologists guide children and their families through the many emotions that come from a cancer diagnosis with in-person and virtual visits. Child Life specialists assist in practical ways, educating your child on what procedures will be like, helping them learn coping strategies for their fears and stress and more. Educational liaisons help communicate and coordinate with your school district so there is a plan for continuing to learn, even when being in the classroom isn’t possible. And families receive the comprehensive support of social workers who can guide adults through the many responsibilities and realities related to caretaking while balancing work and parenting.   

Click here to read more about Siteman Kids’ family services and resources. 

Request an Appointment

Call our nurse navigators to begin setting up an appointment for your child. They are able to answer questions and guide you to resources.