Hong Chen, PhD

Primary Academic Title

Associate Professor of Biomedical Engineering

Research Interest

Ultrasound, one of the most widely used medical imaging modalities, is currently being developed as a noninvasive, targeted therapeutic technique that has incredible potential to transform the treatment of cancer. Prof. Hong Chen’s research focuses on translating basic research advances in ultrasound imaging and therapy into image-guided therapy devices that can impact cancer patient care.

Education

2011: PhD, bioengineering, University of Washington, Seattle

Training

2011 - 2012: Senior fellow, University of Washington, Seattle

Selected Research Publications

In vivo two-photon microscopy imaging of focused ultrasound-mediated glymphatic transport in the mouse brain.

Gong Y, Xu K, Ye D, [...] Chen H
J Cereb Blood Flow Metab 2025

Adeno-associated virus vector delivery to the brain: Technology advancements and clinical applications.

Ye D, Chukwu C, Yang Y, Hu Z, Chen H
Adv Drug Deliv Rev 2024

Airy-beam holographic sonogenetics for advancing neuromodulation precision and flexibility.

Hu Z, Yang Y, Yang L, [...] Chen H
Proc Natl Acad Sci USA 2024

Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection.

Chien CY, Xu L, Yuan J, [...] Chen H
EBioMedicine 2024

Focused Ultrasound-Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model.

Fadera S, Chukwu C, Stark AH, [...] Chen H
Pharmaceutics 2023

First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound.

Yuan J, Xu L, Chien CY, [...] Chen H, Leuthardt EC
NPJ Precis Oncol 2023

Transcranial focused ultrasound-induced blood‒brain barrier opening in mice without shaving hairs.

Xu L, Gong Y, Chien CY, Leuthardt E, Chen H
Sci Rep 2023

Mechanically manipulating glymphatic transport by ultrasound combined with microbubbles.

Ye D, Chen S, Liu Y, [...] Chen H
Proc Natl Acad Sci USA 2023

Characterization of the Targeting Accuracy of a Neuronavigation-Guided Transcranial FUS System In Vitro, In Vivo, and In Silico.

Xu L, Pacia CP, Gong Y, [...] Chen H
IEEE Trans Biomed Eng 2023

Targeted delivery of therapeutic agents to the mouse brain using a stereotactic-guided focused ultrasound device.

Hu Z, Yang Y, Ye D, [...] Chen H
STAR Protoc 2023

Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration.

Ye D, Yuan J, Yang Y, [...] Chen H
EBioMedicine 2022

Blood-brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication.

Chien CY, Xu L, Pacia CP, Yue Y, Chen H
Sci Rep 2022

An Affordable and Easy-to-Use Focused Ultrasound Device for Noninvasive and High Precision Drug Delivery to the Mouse Brain.

Hu Z, Chen S, Yang Y, Gong Y, Chen H
IEEE Trans Biomed Eng 2022

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