Hong Chen, PhD

Primary Academic Title

Associate Professor of Biomedical Engineering

Research Interest

Ultrasound, one of the most widely used medical imaging modalities, is currently being developed as a noninvasive, targeted therapeutic technique that has incredible potential to transform the treatment of cancer. Prof. Hong Chen’s research focuses on translating basic research advances in ultrasound imaging and therapy into image-guided therapy devices that can impact cancer patient care.

Education

2011: PhD, bioengineering, University of Washington, Seattle

Training

2011 - 2012: Senior fellow, University of Washington, Seattle

Selected Research Publications

Focused Ultrasound-Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model.

Fadera S, Chukwu C, Stark AH, [...] Chen H
Pharmaceutics 2023

First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound.

Yuan J, Xu L, Chien CY, [...] Chen H, Leuthardt EC
NPJ Precis Oncol 2023

Transcranial focused ultrasound-induced blood‒brain barrier opening in mice without shaving hairs.

Xu L, Gong Y, Chien CY, Leuthardt E, Chen H
Sci Rep 2023

Mechanically manipulating glymphatic transport by ultrasound combined with microbubbles.

Ye D, Chen S, Liu Y, [...] Chen H
Proc Natl Acad Sci USA 2023

Characterization of the Targeting Accuracy of a Neuronavigation-Guided Transcranial FUS System In Vitro, In Vivo, and In Silico.

Xu L, Pacia CP, Gong Y, [...] Chen H
IEEE Trans Biomed Eng 2023

Targeted delivery of therapeutic agents to the mouse brain using a stereotactic-guided focused ultrasound device.

Hu Z, Yang Y, Ye D, [...] Chen H
STAR Protoc 2023

Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration.

Ye D, Yuan J, Yang Y, [...] Chen H
EBioMedicine 2022

Blood-brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication.

Chien CY, Xu L, Pacia CP, Yue Y, Chen H
Sci Rep 2022

An Affordable and Easy-to-Use Focused Ultrasound Device for Noninvasive and High Precision Drug Delivery to the Mouse Brain.

Hu Z, Chen S, Yang Y, Gong Y, Chen H
IEEE Trans Biomed Eng 2022

Blood-Brain Barrier Opening by Individualized Closed-Loop Feedback Control of Focused Ultrasound.

Chien CY, Yang Y, Gong Y, Yue Y, Chen H
BME Front 2022

Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN).

Ye D, Chen H
Methods Mol Biol 2022

Sonobiopsy for minimally invasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA.

Pacia CP, Yuan J, Yue Y, [...] Chen H
Theranostics 2022

A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit.

Chen S, Nazeri A, Baek H, [...] Chen H
J Cereb Blood Flow Metab 2022

Binary acoustic metasurfaces for dynamic focusing of transcranial ultrasound.

Hu Z, Yang Y, Xu L, Hao Y, Chen H
Front Neurosci 2022

Static Magnetic Fields Dampen Focused Ultrasound-mediated Blood-Brain Barrier Opening.

Yang Y, Pacia CP, Ye D, [...] Chen H
Radiology 2021

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