Marco Colonna, MD

Marco Colonna, MD

Primary Academic Title

Professor of Pathology and Immunology, Section of Immunology and Molecular Pathology, Washington University School of Medicine

Research Interest

We study the cell surface receptors that activate or inhibit the function of natural killer cells and myeloid cells.

Selected Research Publications

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression.
  • Rea A, Santana-Hernández S, Villanueva J, [...] Colonna M, [...] Muntasell A
  • Nat Immunol 2025
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells.
  • Narasimhan H, Richter ML, Shakiba R, [...] Colonna M, [...] Schraml BU
  • Proc Natl Acad Sci USA 2025
Intestinal epithelium-derived IL-34 reprograms macrophages to mitigate gastrointestinal tract graft-versus-host disease.
  • Rayasam A, Moe A, Kudek M, [...] Colonna M, [...] Drobyski WR
  • Sci Transl Med 2025
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.
  • Sultan H, Takeuchi Y, Ward JP, [...] Colonna M, [...] Schreiber RD
  • Nature 2024
Diversity of group 1 innate lymphoid cells in human tissues.
  • Jaeger N, Antonova AU, Kreisel D, [...] Colonna M
  • Nat Immunol 2024
High-dimensional single-cell analysis of human natural killer cell heterogeneity.
  • Rebuffet L, Melsen JE, Escalière B, [...] Colonna M, [...] Vivier E
  • Nat Immunol 2024
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
  • Gaertner F, Ishikawa-Ankerhold H, Stutte S, [...] Colonna M, [...] Massberg S
  • Nature 2024
Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease.
  • Moe A, Rayasam A, Sauber G, [...] Colonna M, [...] Drobyski WR
  • J Clin Invest 2024
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
  • Kirschenbaum D, Xie K, Ingelfinger F, [...] Colonna M, [...] Amit I
  • Cell 2024