Megan Cooper, MD, PhD

Megan Cooper, MD, PhD

Primary Academic Title

Anthony R French Professor of Pediatrics, Division of Pediatric Rheumatology & Immunology, WashU Medicine

Research Interest

Natural killer cells, immune cells capable of targeting and killing cancer cells. Boosting the long-term response of natural killer cell memory by studying the fundamental mechanisms by which these cells can "remember."

Education

  • 2002: PhD, Ohio State University, Columbus
  • 2004: MD, Ohio State University

Training

  • 2004 - 2006: Resident, pediatrics, Washington University, St. Louis
  • 2006 - 2007: Fellow, pediatric rheumatology, Washington University
  • 2007 - 2010: Research fellow, pediatric rheumatology, Washington University

Selected Research Publications

Multicenter international cohort study of haploinsufficiency of A20 reveals novel genetic architecture and phenotypic evolution.
  • He T, Wang J, Carpio Tumba M, [...] Cooper MA, [...] Zhou Q
  • J Allergy Clin Immunol 2026
Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance.
  • Dorando HK, Andrews JM, Khatavkar OU, [...] Cooper MA, [...] Payton JE
  • Blood 2026
Targeted deep sequencing identifies mosaicism in patients with immune dysregulation.
  • Schmitz EG, Paul AJ, Ghosh R, [...] Cooper MA
  • J Allergy Clin Immunol 2026
Clinical relevance of mosaic variants detected by exome sequencing.
  • Ghosh R, Fazal Z, Oler AJ, [...] Cooper MA, [...] Walkiewicz MA
  • J Allergy Clin Immunol 2026
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation.
  • Sohn H, Kolicheski A, Poursine-Laurent J, [...] Cooper MA
  • J Immunol 2025
Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity.
  • Schmitt EG, Saucier N, Risma SI, [...] Cooper MA
  • J Hum Immun 2025
Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells.
  • Bauman BM, Stinson JR, Kallarakal MA, [...] Cooper MA, Snow AL
  • J Exp Med 2025
Identifying genetic errors of immunity due to mosaicism.
  • Schmitz EG, Griffith M, Griffith OL, Cooper MA
  • J Exp Med 2025
Somatic mosaicism in genetic errors of immunity.
  • Cooper MA
  • J Allergy Clin Immunol 2025
Monoallelic expression can govern penetrance of inborn errors of immunity.
  • Stewart O, Gruber C, Randolph HE, [...] Cooper MA, [...] Bogunovic D
  • Nature 2025
MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks.
  • Mathias B, O'Leary D, Saucier N, [...] Cooper MA, [...] Bednarski JJ
  • J Allergy Clin Immunol 2024

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