Megan  Cooper, MD, PhD

Megan Cooper, MD, PhD

Primary Academic Title

Associate Professor of Pediatrics, Division of Pediatric Rheumatology, Washington University School of Medicine

Research Interest

Natural killer cells, immune cells capable of targeting and killing cancer cells. Boosting the long-term response of natural killer cell memory by studying the fundamental mechanisms by which these cells can "remember."


  • 2002: PhD, Ohio State University, Columbus
  • 2004: MD, Ohio State University


  • 2004 - 2006: Resident, pediatrics, Washington University, St. Louis
  • 2006 - 2007: Fellow, pediatric rheumatology, Washington University
  • 2007 - 2010: Research fellow, pediatric rheumatology, Washington University

Selected Research Publications

IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells.
  • Cimpean M, Keppel MP, Gainullina A, [...] Cooper MA
  • J Immunol 2023
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome.
  • Leiding JW, Vogel TP, Santarlas VGJ, [...] Cooper MA, [...] Forbes Satter LR
  • J Allergy Clin Immunol 2023
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue.
  • Sharma R, Sahoo SS, Honda M, [...] Cooper MA, [...] Wlodarski MW
  • Blood 2022
Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion.
  • Mah-Som AY, Keppel MP, Tobin JM, [...] Cooper MA
  • Cell Rep 2021
Lifelong Immune Modulation Versus Hematopoietic Cell Therapy for Inborn Errors of Immunity.
  • Cooper MA, Zimmerman O, Nataraj R, Wynn RF
  • J Allergy Clin Immunol Pract 2021

View All Publications