Megan Cooper, MD, PhD

Megan Cooper, MD, PhD

Primary Academic Title

Associate Professor of Pediatrics, Division of Pediatric Rheumatology, Washington University School of Medicine

Research Interest

Natural killer cells, immune cells capable of targeting and killing cancer cells. Boosting the long-term response of natural killer cell memory by studying the fundamental mechanisms by which these cells can "remember."

Education

  • 2002: PhD, Ohio State University, Columbus
  • 2004: MD, Ohio State University

Training

  • 2004 - 2006: Resident, pediatrics, Washington University, St. Louis
  • 2006 - 2007: Fellow, pediatric rheumatology, Washington University
  • 2007 - 2010: Research fellow, pediatric rheumatology, Washington University

Selected Research Publications

Monoallelic expression can govern penetrance of inborn errors of immunity.
  • Stewart O, Gruber C, Randolph HE, [...] Cooper MA, [...] Bogunovic D
  • Nature 2025
Somatic mosaicism in genetic errors of immunity.
  • Cooper MA
  • J Allergy Clin Immunol 2024
MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks.
  • Mathias B, O'Leary D, Saucier N, [...] Cooper MA, [...] Bednarski JJ
  • J Allergy Clin Immunol 2024
Immunology of Cytokine Storm Syndromes: Natural Killer Cells.
  • French AR, Cron RQ, Cooper MA
  • Adv Exp Med Biol 2024
IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells.
  • Cimpean M, Keppel MP, Gainullina A, [...] Cooper MA
  • J Immunol 2023
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome.
  • Leiding JW, Vogel TP, Santarlas VGJ, [...] Cooper MA, [...] Forbes Satter LR
  • J Allergy Clin Immunol 2023
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue.
  • Sharma R, Sahoo SS, Honda M, [...] Cooper MA, [...] Wlodarski MW
  • Blood 2022

View All Publications