Takeshi Egawa, MD, PhD

Takeshi Egawa, MD, PhD

Primary Academic Title

Associate Professor of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine

Research Interest

Gene regulation that regulates requisite clonal expansion of lymphocytes during the immune responses against infections and cancers and protects proliferating lymphocytes from transformation, c-MYC-initiated gene expression programs that play crucial roles in establishing proliferative states of lymphocytes and also restrict tumorigenesis


  • 1994: MD, Osaka University Medical School, Suita, Osaka, Japan
  • 2002: PhD, medical science and immunology, Osaka University Graduate School of Medicine

Selected Research Publications

Divergent clonal differentiation trajectories of T cell exhaustion.
  • Daniel B, Yost KE, Hsiung S, [...] Egawa T, Satpathy AT
  • Nat Immunol 2022
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.
  • Liu TT, Kim S, Desai P, [...] Egawa T, [...] Murphy KM
  • Nature 2022
Hobit confers tissue-dependent programs to type 1 innate lymphoid cells.
  • Yomogida K, Bigley TM, Trsan T, [...] Egawa T, Colonna M
  • Proc Natl Acad Sci USA 2021
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.
  • Milner JJ, Toma C, Quon S, [...] Egawa T, [...] Goldrath AW
  • J Exp Med 2021
Thymic development of gut-microbiota-specific T cells.
  • Zegarra-Ruiz DF, Kim DV, Norwood K, [...] Egawa T, [...] Diehl GE
  • Nature 2021

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