Obi Griffith, PhD

Obi Griffith, PhD

Primary Academic Title

Professor of Medicine, Division of Oncology, WashU Medicine

Research Interest

My research interests are best described as cancer informatics and clinical statistics with emphasis on use of high-throughput sequencing data in breast cancer. I use computational methods for the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis, prognosis or predicting therapeutic response. My research focuses on understanding how changes in the coding and regulatory sequences of DNA contribute to cancer development and progression.

Education

  • 2008: PhD, medical genetics, University of British Columbia, Vancouver, British Columbia, Canada

Training

  • 2008 - 2010: Postdoctoral fellow, medical genetics, British Columbia Cancer Agency, Canada’s Michael Smith Genome Sciences Centre, Vancouver
  • 2010 - 2012: Postdoctoral fellow, cancer and DNA damage, Lawrence Berkeley National Laboratory, Berkeley, Calif.

Selected Research Publications

Targeted deep sequencing identifies mosaicism in patients with immune dysregulation.
  • Schmitz EG, Paul AJ, Ghosh R, [...] Griffith OL, [...] Cooper MA
  • J Allergy Clin Immunol 2026
Searching the Druggable Genome using Large Language Models.
  • Schimmelpfennig L, Cannon M, Cody Q, [...] Griffith OL
  • bioRxiv 2026
CIViC MCP: Integrating Large Language Models with the Clinical Interpretations of Variants in Cancer.
  • Schimmelpfennig L, Cody Q, McMichael J, [...] Griffith OL
  • bioRxiv 2025
Large B cell lymphoma microenvironment archetype profiles.
  • Li X, Singhal K, Deng Q, [...] Griffith OL, [...] Green MR
  • Cancer Cell 2025
Identifying genetic errors of immunity due to mosaicism.
  • Schmitz EG, Griffith M, Griffith OL, Cooper MA
  • J Exp Med 2025
pVACview: an interactive visualization tool for efficient neoantigen prioritization and selection.
  • Xia H, Hoang MH, Schmidt E, [...] Griffith OL, Griffith M
  • Genome Med 2024
A New Era of Data-Driven Cancer Research and Care: Opportunities and Challenges.
  • Gomez F, Danos AM, Del Fiol G, [...] Griffith OL
  • Cancer Discov 2024
Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation.
  • Foltz JA, Tran J, Wong P, [...] Griffith OL, [...] Fehniger TA
  • Sci Immunol 2024
Single-cell T-cell receptor repertoire profiling in dogs.
  • Hoang MH, Skidmore ZL, Rindt H, [...] Griffith OL
  • Commun Biol 2024
DGIdb 5.0: rebuilding the drug-gene interaction database for precision medicine and drug discovery platforms.
  • Cannon M, Stevenson J, Stahl K, [...] Griffith OL, [...] Wagner AH
  • Nucleic Acids Res 2024
Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.
  • Gomez F, Fisk B, McMichael JF, [...] Griffith OL
  • Cancer Res Commun 2023
T-BET and EOMES sustain mature human NK cell identity and antitumor function.
  • Wong P, Foltz JA, Chang L, [...] Griffith OL, [...] Fehniger TA
  • J Clin Invest 2023

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