Timothy Ley, MD

Timothy Ley, MD

Primary Academic Title

Lewis T. and Rosalind B. Apple Professor of Oncology in Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine

Research Interest

Regulation of globin gene expression; regulation of gene expression during myelomonocytic development (cathepsin G) and T-Cell activation (Gzm B and H); functions of serine proteases in immune effector cells.

Education

  • 1978: MD, Washington University, St. Louis

Training

  • 1978 - 1980: Intern and resident, Massachusetts General Hospital, Boston
  • 1980 - 1983: Postdoctoral fellow, molecular hematology, National Heart, Blood and Lung Institute, Bethesda, Md.
  • 1083 - 1984: Fellow, hematology/oncology, Washington University, St. Louis

Selected Research Publications

Melanoma in a patient with DNMT3A overgrowth syndrome.
  • Chen DY, Sutton LA, Ramakrishnan SM, [...] Ley TJ
  • Cold Spring Harb Mol Case Stud 2023
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.
  • Ryland GL, Umeda M, Holmfeldt L, [...] Ley TJ, [...] Klco JM
  • Blood 2023
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.
  • Kramer MH, Zhang Q, Sprung R, [...] Ley TJ
  • Blood 2022
Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy.
  • Ferraro F, Gruszczynska A, Ruzinova MB, [...] Ley TJ, Welch JS
  • Haematologica 2022
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
  • Wilson ER, Helton NM, Heath SE, [...] Ley TJ, Spencer DH
  • Leukemia 2022