Timothy Lohman, PhD

Timothy Lohman, PhD

Primary Academic Title

Marvin A. Brennecke Professor of Biological Chemistry, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine

Research Interest

Mechanisms of DNA unwinding and translocation of DNA helicases and SSB proteins.


  • 1977: PhD, physical chemistry, University of Wisconsin, Madison


  • 1977 - 1979: Postdoctoral associate, biophysical chemistry, University of California, San Diego
  • 1979 - 1981: Postdoctoral fellow, physical biochemistry, University of Oregon, Eugene

Selected Research Publications

"Helicase" Activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein.
  • Mersch KN, Sokoloski JE, Nguyen B, Galletto R, Lohman TM
  • Proc Natl Acad Sci USA 2023
Allosteric effects of E. coli SSB and RecR proteins on RecO protein binding to DNA.
  • Shinn MK, Chaturvedi SK, Kozlov AG, Lohman TM
  • Nucleic Acids Res 2023
Regulation of E. coli Rep helicase activity by PriC.
  • Nguyen B, Shinn MK, Weiland E, Lohman TM
  • J Mol Biol 2021

View All Publications