Melanoma, skin cancer, dermatology, cutaneous oncology
Our laboratory focus is on endothelial cells and angiogenesis, specifically tumor angiogenesis. Recent studies have identified angiostatin that inhibits tumor angiogenesis and metastasis. We have demonstrated that macrophage metalloelastase generates biologically functional angiostatin, an inhibitor of tumor angiogenesis. We are using mouse models, and also studying human melanoma tumors, for the presence and type of inflammatory response, angiogenesis, the presence of angiostatin and the expression of angiostatin-generating enzymes to determine their relationship to the presence or absence of metastasis. We are also following patients with melanoma and atypical nevi clinically, using digital photography and specialized computer software.
- 1984: MD, University of Missouri, Columbia
- 1984 - 1985: Intern, internal medicine, University of North Carolina, Chapel Hill
- 1985 - 1986: Fellow, dermatology, University of North Carolina, Chapel Hill
- 1986 - 1989: Resident and chief resident, dermatology, Washington University, St. Louis
- 1989 - 1993: Fellow, immunodermatology, Emory University, Atlanta
- 1989: American Board of Dermatology
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