Michael Ben Major, PhD

Michael Ben Major, PhD

Primary Academic Title

Professor of Cell Biology and Physiology, Washington University School of Medicine

Research Interest

Understanding how alterations in signal transduction pathways contribute to human cancer, and whether exploitation of that understanding can aid in the development of new diagnostics, prognosis and therapeutic intervention strategies


  • 2004: PhD, University of Utah, Salt Lake City


  • 2007 - 2009: Postdoctoral, pharmacology, University of Washington, Seattle

Selected Research Publications

Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia.
  • Paiboonrungruang C, Xiong Z, Lamson D, [...] Ben Major M, Chen X
  • Redox Biol 2023
Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
  • Wamsley NT, Wilkerson EM, Guan L, [...] Major MB
  • Mol Cell Proteomics 2023
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
  • Zhang J, Walker ME, Sanidad KZ, [...] Major MB, [...] Zhang G
  • Nat Commun 2022

View All Publications