Gabriel Mbalaviele, PhD

Gabriel Mbalaviele, PhD

Primary Academic Title

Professor of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine

Research Interest

Role of inflammasomes and gasdermins in pathophysiology.


  • 1992: PhD, University of Paris 7


  • 2007 - 2010: Associate research fellow, St. Louis, Mo.

Selected Research Publications

Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.
  • Khanna K, Yan H, Mehra M, [...] Mbalaviele G, [...] Faccio R
  • Arthritis Rheumatol 2024
Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis.
  • Xiao J, Sun K, Wang C, Abu-Amer Y, Mbalaviele G
  • J Transl Autoimmun 2022
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria.
  • González-Dominguez A, Montañez R, Castejón-Vega B, [...] Mbalaviele G, [...] Cordero MD
  • EMBO Mol Med 2021

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