Jeffrey Miner, PhD

Jeffrey Miner, PhD

Primary Academic Title

Professor of Medicine, Renal Division, Washington University School of Medicine

Research Interest

My lab is interested in the roles of basement membranes in mammalian development and disease, with particular emphasis on the kidney. We study two major classes of basement membrane components: laminins and type IV collagens. We have generated transgenic and knockout mouse models for human kidney diseases in order to investigate the functions of basement membrane proteins in normal physiological processes. We have new evidence that laminins influence either proliferation of apoptosis of intestinal cells. We are also studying a receptor that interacts with laminin, the Lutheran blood group glycoprotein/basal cell adhesion molecule (B-CAM). B-CAM is expressed on the surface of some epithelial cancer cells.

Education

  • 1991: PhD, molecular biology and biochemistry, California Institute of Technology, Pasadena

Training

  • 1991 - 1992: Postdoctoral fellow, developmental biology, California Institute of Technology, Pasadena
  • 1992 - 1996: Postdoctoral fellow, cell and developmental biology, Washington University School of Medicine, St. Louis

Selected Research Publications

Identification of an Altered Matrix Signature in Kidney Aging and Disease.
  • Randles MJ, Lausecker F, Kong Q, [...] Miner J, Lennon R
  • J Am Soc Nephrol 2021

View All Publications

Contact Information

Contact Information