Kenneth Murphy, MD, PhD

Kenneth Murphy, MD, PhD

Primary Academic Title

Professor of Pathology and Immunology, Division of Immunology and Molecular Pathology, Washington University School of Medicine

Research Interest

Regulation of T helper cell differentiation, mechanism of cytokine-induced differentiation and regulation of cytokine gene expression.

Education

  • 1984: MD/ PhD, Johns Hopkins University, Baltimore

Training

  • 1986 - 1990: Postdoctoral fellow, Washington University, St. Louis

Selected Research Publications

Identification of antigen-presenting cell-T cell interactions driving immune responses to food.
  • Campos Canesso MC, de Castro TBR, Nakandakari-Higa S, [...] Murphy KM, [...] Mucida D
  • Science 2025
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.
  • Sultan H, Takeuchi Y, Ward JP, [...] Murphy KM, [...] Schreiber RD
  • Nature 2024
Anatomy of a superenhancer.
  • Kim S, Liu TT, Ou F, Murphy TL, Murphy KM
  • Adv Immunol 2024
IL-6 selectively suppresses cDC1 specification via C/EBPβ.
  • Kim S, Chen J, Jo S, [...] Murphy KM
  • J Exp Med 2023
Bcl6, Irf2, and Notch2 promote nonclassical monocyte development.
  • O'Connor KW, Liu T, Kim S, [...] Murphy KM
  • Proc Natl Acad Sci USA 2023
The evolving biology of cross-presentation.
  • Ohara RA, Murphy KM
  • Semin Immunol 2023
The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain.
  • Bowman-Kirigin JA, Desai R, Saunders BT, [...] Murphy KM, [...] Dunn GP
  • Cancer Immunol Res 2023
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation.
  • Wu R, Ohara RA, Jo S, [...] Murphy KM
  • Nat Immunol 2022

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