Kenneth Murphy, MD, PhD

Kenneth Murphy, MD, PhD

Primary Academic Title

Professor of Pathology and Immunology, Division of Immunology and Molecular Pathology, Washington University School of Medicine

Research Interest

Regulation of T helper cell differentiation, mechanism of cytokine-induced differentiation and regulation of cytokine gene expression.


  • 1984: MD/ PhD, Johns Hopkins University, Baltimore


  • 1986 - 1990: Postdoctoral fellow, Washington University, St. Louis

Selected Research Publications

IL-6 selectively suppresses cDC1 specification via C/EBPβ.
  • Kim S, Chen J, Jo S, [...] Murphy KM
  • J Exp Med 2023
Bcl6, Irf2, and Notch2 promote nonclassical monocyte development.
  • O'Connor KW, Liu T, Kim S, [...] Murphy KM
  • Proc Natl Acad Sci USA 2023
The evolving biology of cross-presentation.
  • Ohara RA, Murphy KM
  • Semin Immunol 2023
The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain.
  • Bowman-Kirigin JA, Desai R, Saunders BT, [...] Murphy KM, [...] Dunn GP
  • Cancer Immunol Res 2023
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation.
  • Wu R, Ohara RA, Jo S, [...] Murphy KM
  • Nat Immunol 2022
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.
  • Liu TT, Kim S, Desai P, [...] Murphy KM
  • Nature 2022
Dendritic cells in cancer immunology.
  • Murphy TL, Murphy KM
  • Cell Mol Immunol 2022

View All Publications