Kenneth Murphy, MD, PhD

Kenneth Murphy, MD, PhD

Primary Academic Title

Professor of Pathology and Immunology, Division of Immunology and Molecular Pathology, Washington University School of Medicine

Research Interest

Regulation of T helper cell differentiation, mechanism of cytokine-induced differentiation and regulation of cytokine gene expression.

Education

  • 1984: MD/ PhD, Johns Hopkins University, Baltimore

Training

  • 1986 - 1990: Postdoctoral fellow, Washington University, St. Louis

Selected Research Publications

WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route.
  • Postoak JL, Koch A, Shan S, [...] Murphy KM
  • Proc Natl Acad Sci USA 2025
Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.
  • Hogg GD, Weinstein AG, Kingston NL, [...] Murphy KM, [...] DeNardo DG
  • Sci Immunol 2025
Identification of antigen-presenting cell-T cell interactions driving immune responses to food.
  • Campos Canesso MC, de Castro TBR, Nakandakari-Higa S, [...] Murphy KM, [...] Mucida D
  • Science 2025
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.
  • Sultan H, Takeuchi Y, Ward JP, [...] Murphy KM, [...] Schreiber RD
  • Nature 2024
Anatomy of a superenhancer.
  • Kim S, Liu TT, Ou F, Murphy TL, Murphy KM
  • Adv Immunol 2024
IL-6 selectively suppresses cDC1 specification via C/EBPβ.
  • Kim S, Chen J, Jo S, [...] Murphy KM
  • J Exp Med 2023
Bcl6, Irf2, and Notch2 promote nonclassical monocyte development.
  • O'Connor KW, Liu T, Kim S, [...] Murphy KM
  • Proc Natl Acad Sci USA 2023

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