Alessandro Vindigni, PhD

Alessandro Vindigni, PhD

Primary Academic Title

Associate Professor of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

Research Interest

Aberrant DNA replication is one of the leading causes of mutations and chromosome rearrangements associated with several cancer related pathologies. At the same time, agents that stall or damage DNA replication forks are widely used for chemotherapy, in the attempt to selectively target highly proliferating cancer cells. Our group studies the mechanisms that operate in eukaryotic cells to maintain replication fork integrity upon chemical treatment with cancer chemotherapeutics.

Education

  • 1995: PhD, biochemistry and molecular biophysics, University of Padua, Padua, Italy

Training

  • 1995 - 1999: Postdoctural fellow, Washington University

Selected Research Publications

A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells.
  • Cybulla E, Wallace S, Meroni A, [...] Vindigni A
  • Nucleic Acids Res 2024
The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress.
  • Fingerman DF, O'Leary DR, Hansen AR, [...] Vindigni A, [...] Green AM
  • EMBO J 2024
Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells.
  • Ramakrishnan N, Weaver TM, Aubuchon LN, [...] Vindigni A, [...] Verma P
  • Nat Commun 2024
DNA combing versus DNA spreading and the separation of sister chromatids.
  • Meroni A, Wells SE, Fonseca C, [...] Vindigni A
  • J Cell Biol 2024
RAD51 bypasses the CMG helicase to promote replication fork reversal.
  • Liu W, Saito Y, Jackson J, [...] Vindigni A, Cortez D
  • Science 2023
NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors.
  • Meroni A, Grosser J, Agashe S, [...] Vindigni A
  • Sci Adv 2022

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