Alessandro Vindigni, PhD

Alessandro Vindigni, PhD

Primary Academic Title

Associate Professor of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

Research Interest

Aberrant DNA replication is one of the leading causes of mutations and chromosome rearrangements associated with several cancer related pathologies. At the same time, agents that stall or damage DNA replication forks are widely used for chemotherapy, in the attempt to selectively target highly proliferating cancer cells. Our group studies the mechanisms that operate in eukaryotic cells to maintain replication fork integrity upon chemical treatment with cancer chemotherapeutics.


  • 1995: PhD, biochemistry and molecular biophysics, University of Padua, Padua, Italy


  • 1995 - 1999: Postdoctural fellow, Washington University

Selected Research Publications

DNA combing versus DNA spreading and the separation of sister chromatids.
  • Meroni A, Wells SE, Fonseca C, [...] Vindigni A
  • J Cell Biol 2024
RAD51 bypasses the CMG helicase to promote replication fork reversal.
  • Liu W, Saito Y, Jackson J, [...] Vindigni A, Cortez D
  • Science 2023
NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors.
  • Meroni A, Grosser J, Agashe S, [...] Vindigni A
  • Sci Adv 2022
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
  • Tsao N, Brickner JR, Rodell R, [...] Vindigni A, [...] Mosammaparast N
  • Mol Cell 2021
RADX prevents genome instability by confining replication fork reversal to stalled forks.
  • Krishnamoorthy A, Jackson J, Mohamed T, [...] Vindigni A, Cortez D
  • Mol Cell 2021

View All Publications