Clinical Trials in Pancreas Cancer

Clinical trials are research studies that provide hope for patients with cancer. These trials give patients access to new treatment therapies including new drugs or new ways to use existing drugs. They also include new radiation therapies, new surgical procedures, and new ways to combine different cancer treatments.

The ultimate goal of each clinical trial is to find new and improved ways to safely and effectively treat cancer. Clinical trials are important to patients because they give access to treatment that would not be provided otherwise. In addition, they are important because they help get drugs approved and more easily accessible for future patients.

If you are interested in learning more about the Pancreas SPORE clinical trials, you should ask your doctor or nurse if a clinical trial is available and appropriate for you. Below are current clinical trials the Pancreas SPORE investigators are researching.

NeoAdjuvant

NCT03122106: Neoantigen DNA Vaccine in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy

The purpose of this research study is to learn more about the safety and feasibility of injecting a personalized DNA vaccine into people with pancreatic cancer. Injection of this DNA vaccine may be a way to generate an immune response to tumor cells and help fight cancer.

Locally Advanced

BMS-813160 With Nivolumab and Gemcitabine and Nab-paclitaxel in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC)

The purpose of this research study is to learn what the best dose is of the investigational drugs nivolumab and BMS-813160 when combining them with the currently approved drugs for pancreatic cancer, gemcitabine and nab-paclitaxel.

Nab-Paclitaxel Plus Gemcitabine With Concurrent MR-Guided IMRT in Patients With Locally Advanced Pancreatic Cancer

The purpose of this research study is to find the highest dose of radiation that can be safely given during chemoradiotherapy with modern chemotherapy agents to treat pancreas cancer. In addition, the machine being used to administer the radiation therapy uses a technique called magnetic resonance imaging (MRI)-guided adaptive radiation therapy. MRI-guided adaptive radiation therapy involves the adjustment or re-planning of treatment day by day while you are receiving treatment.

Metastatic

Defactinib Combined With Pembrolizumab and Gemcitabine in Patients With Advanced Cancer

The purpose of this research study is to test the combination of three drugs called defactinib, pembrolizumab, and gemcitabine for the treatment of  pancreatic cancer.  The study will help us discover what the best dose of each drug is and how well the combination treats pancreatic cancer.

BVD-523 Plus Nab-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Cancer

The purpose of this research study is to learn more about the combination of three drugs – BVD-523, gemcitabine, and nab-paclitaxel – for the treatment of metastatic pancreatic cancer. We will be looking at how well these drugs are able to control pancreatic cancer growth.

A Phase 1b/2 Study of BMS-813160 in Combination with Chemotherapy or Nivolumab in Patients with Advanced Solid Tumors

The purpose of this research study is to discover if patient are treated with an immunotherapy drug, called BMS-813160, alone or together with another immunotherapy drug, called nivolumab or chemotherapy have better control of their cancer than patients who do not receive the immunotherapy drugs.

A Phase III Study of BBI-608 plus nab-Paclitaxel with Gemcitabine in Adult Patients with Metastatic Pancreatic Adenocarcinoma

The purpose of this research study is to find out whether participants with pancreatic cancer live longer when receiving an experiment treatment with an investigational drug, BBI-608, in combination with standard chemotherapy (nab-Paclitaxel and Gemcitabine) compared to patients who are treated with standard chemotherapy alone. 201611106 The purpose of this research study is to create a patient registry and tissue bank in order to identify early biomarkers for pancreatic disease, and to develop better tests and treatments for pancreatic disease.

A Phase 2 Study of Cabiralizumab (BMS-986227, FPA008) Administered in Combination with Nivolumab (BMS-936558) with and without Chemotherapy in Patients with Advanced Pancreatic Cancer

The purpose of this research study is to test the effectiveness of the combination of cabiralizumab (BMS-986227) and nivolumab with and without chemotherapy for the treatment of advanced/metastatic pancreatic cancer.

A Phase II Multi-Center Study of SM-88 in Subjects with Pancreatic Cancer Whose Disease Has Progressed or Recurred after/on First Line Chemotherapy

The purpose of this research study is to find the appropriate dose of SM-88, an experimental drug regimen, and see how well it works to treat pancreatic cancer.