Four Siteman Cancer Center research members inducted as AIMBE fellows

Four Washington University faculty members who also are research members of Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine have been named fellows of the American Institute for Medical and Biological Engineering (AIMBE).

The four – Tammie L.S. Benzinger, MD, PhD; Joseph P. Culver, PhD; Alexander H. Stegh, PhD; and Ting Wang, PhD – are among 162 colleagues inducted March 25 in Arlington, Va.

Election to AIMBE’s College of Fellows is limited to the top 2% of medical and biological engineers in these fields. Those elected are considered to have made outstanding contributions to engineering and medicine research, practice or education.

Learn more about the four researchers and their work below.

Tammie L.S. Benzinger, MD, PhD

Neuroradiologist Tammie L.S. Benzinger, MD, PhD, uses imaging to investigate biomarkers in aging and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis. Biomarkers are biological signs that can be used to diagnose disease, predict progression and track the response to treatment. Benzinger uses a variety of advanced imaging techniques to measure inflammation in the brain, a key element of many neurodegenerative conditions. She also uses imaging of the key Alzheimer’s proteins amyloid beta and tau to investigate how the disease develops and progresses, and how it differs from healthy aging.

A professor of radiology and of neurosurgery, Benzinger also serves as the chief of the MRI service and is a member of the neuroradiology section at the School of Medicine’s Mallinckrodt Institute of Radiology.

 

Joseph P. Culver, PhD

Joseph P. Culver, the Sherwood Moore Professor of Radiology at the School of Medicine, is a pioneer in using the power of light to image the brain noninvasively. For humans, his work has advanced the technique of diffuse optical tomography (DOT), which uses interlaced arrays of tiny lights and detectors placed on the outside of the head to track what the brain is doing. Among other achievements, his group designed a wearable DOT-based cap — now under commercial development — to image people’s brains under naturalistic conditions. For mice, his group has pioneered resting state technics for mapping brain networks, with broad applications in preclinical models of neurological disease.

At the School of Medicine’s Mallinckrodt Institute of Radiology, Culver directs the Biophotonics Research Center, which harnesses light to develop methods for understanding, diagnosing and treating human diseases. He also serves as co-director of Washington University’s imaging science PhD program.

 

Alexander H. Stegh, PhD

Alexander H. Stegh, is a professor of neurosurgery at the School of Medicine and a national leader in the study of glioblastoma, one of the most aggressive forms of brain cancer. His research focuses on uncovering genetic drivers of glioblastoma through a combination of cellular and molecular biology, engineered mouse models, and oncogenomics, the latter of which is a subfield of genomics that characterizes cancer-associated genes.

Additionally, Stegh’s research is noted for pioneering efforts to develop nanotechnologies to dial down the expression of oncogenes and activate anti-tumor immune responses. His success in translating nanoparticle-based precision medicine approaches to brain cancer patients has led to a clinical trial in people involving gene-regulatory spherical nucleic acids (SNAs) for the treatment of recurrent glioblastoma.

Stegh is also vice chair of research in the Department of Neurosurgery and research director of the Brain Tumor Center at Siteman.

 

Ting Wang, PhD

Ting Wang, the Sanford C. and Karen P. Loewentheil Distinguished Professor of Medicine and head of the Department of Genetics at the School of Medicine, studies how genes are regulated in health and disease, with a focus on the genetics and epigenetics of cancer.

Wang has led groundbreaking studies in how the genome is regulated through the lens of transposable elements — short pieces of the genome that have changed locations over the course of human evolution. Transposable elements can change how a gene is expressed, potentially causing diseases such as cancer.

Wang holds major leadership roles in several national genomics collaborations, including the Human Pangenome Reference Consortium and the Somatic Mosaicism across Human Tissues Network. He was nominated for his development of computational methods and visualization techniques to create large genomics resources for the scientific community. The human pangenome project aims to create a human genome reference that better represents genetic diversity. Somatic mosaicism refers to changes to our DNA that occur after conception and that lead to some cells having different DNA sequences than others.

 

Source: The Record