Epigenetics is the study of how our behaviors and environments can affect the way our genes work. Our investigators hypothesize that epigenetic changes in the tumor and surrounding environment contribute to therapy resistance and recurrence. Re-defining patients’ glioblastoma tumors through this lens offers the exciting prospect of discovering new cancer cell vulnerabilities.

Inhibitors of chromatin & DNA modifiers

We are evaluating the ability of certain drugs to enhance therapeutic approaches by inhibiting epigenetic adaptability, thus “locking” tumor cells in a treatment-sensitive state.

Epigenetic control of non-coding DNA

We are testing the theory that epigenetic therapies can make cancer cells more sensitive to immunotherapies by triggering the expression of DNA sequences that can change their position within the genome.

Epigenetic changes of metabolic adaptation

We are studying and targeting the precise ways in which metabolites control enzymes involved in DNA and histone modifications, as well as how those metabolites shape the tumor’s DNA.