Clinical Trials for Colorectal Cancer

201107221

Tissue and Blood Acquisition for Genomic Analysis and Collection of Health Information for Patients with Gastrointestinal Cancers Phase N/A Principal Investigator Park, Haeseong Disease Site Colon; Esophagus; Ill-Defined Sites; Larynx; Liver; Other Digestive Organ; Pancreas;…

201710148

A Multi-Center, Open-Label, Phase 1/1b Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anticancer Activity of Fruquintinib in Patients with Advanced Solid Tumors Phase I Principal Investigator Park, Haeseong Disease Site Anus; Brain and…

201710206

Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair Phase III Principal Investigator Pedersen, Katrina Disease Site Colon Learn…

201712097

A Randomized Phase II Study of Trastuzumab and Pertuzumab (TP) Compared to Cetuximab and Irinotecan (Cetiri) in Advanced/Metastatic Colorectal Cancer (MCRC) with Her-2 Applification Phase II Principal Investigator Tan, Benjamin Disease Site Colon; Rectum Learn…

201805117

A Phase Ib/II Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-based Treatment Combinations in Patients with Metastatic Colorectal Cancer (MORPHEUS-CRC) Phase I/II Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum…

201906169

Phase 1b/2 Open-label Study to Evaluate the Safety, Tolerability and Efficacy of Rivoceranib or Trifluridine/Tipiracil as Monotherapies and Rivoceranib and Trifluridine/Tipiracil as Combination Therapy in Subjects with Metastatic Colorectal Cancer Phase I/II Principal Investigator Trikalinos,…

201909063

A Phase I, First-In-Human, Multicenter, Open-Label Study of Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors Phase I Principal Investigator Pedersen, Katrina Disease Site Colon; Other Digestive Organ; Rectum; Stomach Learn more…

201911080

A Phase II Study to Evaluate the Safety and Efficacy of OQL011 on VEGFR Inhibitor-Associated Hand-foot Skin Reaction in Cancer Patients Study Number OQL011B002 Phase II Principal Investigator Anadkat, Milan Disease Site Acute Myeloid Leukemia…

201912123

RANDOMIZED DOUBLE-BLIND PHASE III TRIAL OF VITAMIN D3 SUPPLEMENTATION IN PATIENTS WITH PREVIOUSLY UNTREATED METASTATIC COLORECTAL CANCER (SOLARIS) Phase III Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about this study at: clinicaltrials.gov

202001128

A phase I/Ib, open-label, multi-center, study of KAZ954 as a single agent and in combination with Spartalizumab, NZV930 and NIR178 in patients with advanced solid tumors Phase Early Phase I (Cancer Control) Principal Investigator Park,…

202003057

Phase II/III Study of Circulating tumOr DNA as a Predictive BiomaRker in Adjuvant Chemotherapy in Patients with Stage IIA Colon Cancer (COBRA) Phase II/III Principal Investigator Pedersen, Katrina Disease Site Colon Learn more about this…

202003096

A Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation Phase I/II (Cancer Control) Principal Investigator Park, Haeseong Disease Site Colon; Corpus Uteri; Lung; Ovary;…

202005035

BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer Phase N/A Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about this study at: clinicaltrials.gov

202006123

Phase Ib study of gevokizumab in combination with standard of care anti-cancer therapies in patients with metastatic colorectal cancer, gastroesophageal cancer and renal cell carcinoma Phase I Principal Investigator Pedersen, Katrina Disease Site Colon; Esophagus;…

202006133

A phase 1b dose escalation study of tucatinib in combination with trastuzumab and oxaliplatin-based chemotherapy for HER2+ gastrointestinal cancers Phase I/II Principal Investigator Park, Haeseong Disease Site Colon; Esophagus; Other Digestive Organ; Rectum; Stomach Learn…

202007217

A MULTI-CENTER, OPEN-LABEL, PHASE 2 STUDY TO EVALUATE SAFETY AND EFFICACY OF U3-1402 IN SUBJECTS WITH ADVANCED OR METASTATIC COLORECTAL CANCER (CRC) Phase II Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about…

201902040

Phase I study of epacadostat (INCB024360) added to preoperative chemoradiation in patients with locally advanced rectal cancer Phase I Principal Investigator Park, Haeseong Disease Site Rectum Learn more about this study at: clinicaltrials.gov

201904029

Non-Operative Management and Early Response Assessment in Rectal Cancer (NOM-ERA) Phase II Principal Investigator Kim, Hyun Disease Site Rectum Learn more about this study at: clinicaltrials.gov

202103218

Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy (IMPT) in the Reirradiation of Locoregionally Recurrent Rectal Cancer – IMPARC Phase N/A Principal Investigator Badiyan, Shahed Disease Site Anus; Colon; Rectum Learn more about this study at: clinicaltrials.gov

201708029

A Multi-Institutional Phase 2 Study of Nivolumab in Refractory Metastatic Squamous Cell Carcinoma of the Anal Canal Phase II Principal Investigator Aranha, Olivia Disease Site Anus Learn more about this study at: clinicaltrials.gov

202003005

A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) EA2182 Phase II Principal Investigator Henke, Lauren Disease Site Anus Learn more about this study at: clinicaltrials.gov

202011055

A Randomized Phase III Study of Immune Checkpoint Inhibition with Chemotherapy in Treatment-Naïve Metastatic Anal Cancer Patients Phase III Principal Investigator Aranha, Olivia Disease Site Anus Learn more about this study at: clinicaltrials.gov

201107221

Tissue and Blood Acquisition for Genomic Analysis and Collection of Health Information for Patients with Gastrointestinal Cancers Phase N/A Principal Investigator Park, Haeseong Disease Site Colon; Esophagus; Ill-Defined Sites; Larynx; Liver; Other Digestive Organ; Pancreas;…

201708029

A Multi-Institutional Phase 2 Study of Nivolumab in Refractory Metastatic Squamous Cell Carcinoma of the Anal Canal Phase II Principal Investigator Aranha, Olivia Disease Site Anus Learn more about this study at: clinicaltrials.gov

201710148

A Multi-Center, Open-Label, Phase 1/1b Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anticancer Activity of Fruquintinib in Patients with Advanced Solid Tumors Phase I Principal Investigator Park, Haeseong Disease Site Anus; Brain and…

201710206

Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair Phase III Principal Investigator Pedersen, Katrina Disease Site Colon Learn…

201712097

A Randomized Phase II Study of Trastuzumab and Pertuzumab (TP) Compared to Cetuximab and Irinotecan (Cetiri) in Advanced/Metastatic Colorectal Cancer (MCRC) with Her-2 Applification Phase II Principal Investigator Tan, Benjamin Disease Site Colon; Rectum Learn…

201805117

A Phase Ib/II Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-based Treatment Combinations in Patients with Metastatic Colorectal Cancer (MORPHEUS-CRC) Phase I/II Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum…

201808122

Randomized, Double-blinded Phase III Study of Cabozantinib versus Placebo in Patients with Advanced Neuroendocrine Tumors after Progression on Everolimus Phase III Principal Investigator Trikalinos, Nikolaos Disease Site Anus; Colon; Esophagus; Liver; Lung; Other Digestive Organ;…

201902040

Phase I study of epacadostat (INCB024360) added to preoperative chemoradiation in patients with locally advanced rectal cancer Phase I Principal Investigator Park, Haeseong Disease Site Rectum Learn more about this study at: clinicaltrials.gov

201904029

Non-Operative Management and Early Response Assessment in Rectal Cancer (NOM-ERA) Phase II Principal Investigator Kim, Hyun Disease Site Rectum Learn more about this study at: clinicaltrials.gov

201906169

Phase 1b/2 Open-label Study to Evaluate the Safety, Tolerability and Efficacy of Rivoceranib or Trifluridine/Tipiracil as Monotherapies and Rivoceranib and Trifluridine/Tipiracil as Combination Therapy in Subjects with Metastatic Colorectal Cancer Phase I/II Principal Investigator Trikalinos,…

201909063

A Phase I, First-In-Human, Multicenter, Open-Label Study of Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors Phase I Principal Investigator Pedersen, Katrina Disease Site Colon; Other Digestive Organ; Rectum; Stomach Learn more…

201911080

A Phase II Study to Evaluate the Safety and Efficacy of OQL011 on VEGFR Inhibitor-Associated Hand-foot Skin Reaction in Cancer Patients Study Number OQL011B002 Phase II Principal Investigator Anadkat, Milan Disease Site Acute Myeloid Leukemia…

201912123

RANDOMIZED DOUBLE-BLIND PHASE III TRIAL OF VITAMIN D3 SUPPLEMENTATION IN PATIENTS WITH PREVIOUSLY UNTREATED METASTATIC COLORECTAL CANCER (SOLARIS) Phase III Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about this study at: clinicaltrials.gov

202001128

A phase I/Ib, open-label, multi-center, study of KAZ954 as a single agent and in combination with Spartalizumab, NZV930 and NIR178 in patients with advanced solid tumors Phase Early Phase I (Cancer Control) Principal Investigator Park,…

202001226

Randomized Phase II Selection Study of Ramucirumab and Paclitaxel versus FOLFIRI in Refractory Small Bowel Adenocarcinoma Phase II Principal Investigator Pedersen, Katrina Disease Site Small Intestine Learn more about this study at: clinicaltrials.gov

202003005

A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) EA2182 Phase II Principal Investigator Henke, Lauren Disease Site Anus Learn more about this study at: clinicaltrials.gov

202003057

Phase II/III Study of Circulating tumOr DNA as a Predictive BiomaRker in Adjuvant Chemotherapy in Patients with Stage IIA Colon Cancer (COBRA) Phase II/III Principal Investigator Pedersen, Katrina Disease Site Colon Learn more about this…

202003096

A Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation Phase I/II (Cancer Control) Principal Investigator Park, Haeseong Disease Site Colon; Corpus Uteri; Lung; Ovary;…

202005035

BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer Phase N/A Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about this study at: clinicaltrials.gov

202006123

Phase Ib study of gevokizumab in combination with standard of care anti-cancer therapies in patients with metastatic colorectal cancer, gastroesophageal cancer and renal cell carcinoma Phase I Principal Investigator Pedersen, Katrina Disease Site Colon; Esophagus;…

202006133

A phase 1b dose escalation study of tucatinib in combination with trastuzumab and oxaliplatin-based chemotherapy for HER2+ gastrointestinal cancers Phase I/II Principal Investigator Park, Haeseong Disease Site Colon; Esophagus; Other Digestive Organ; Rectum; Stomach Learn…

202007122

Blood acquisition for circulating tumor DNA (ctDNA) analysis for patients undergoing peptide receptor radionuclide therapy (PRRT) in patients with metastatic unresectable gastroenteropancreatic neuroendocrine tumors (GEP-NETs) Phase N/A Principal Investigator Trikalinos, Nikolaos Disease Site Other Digestive…

202007173

Cabozantinib in high grade neuroendocrine neoplasms Phase II Principal Investigator Trikalinos, Nikolaos Disease Site Brain and Nervous System; Colon; Lung; Other Digestive Organ; Other Endocrine System; Other Respiratory and Intrathoracic Organs; Other Skin; Pancreas; Prostate;…

202007217

A MULTI-CENTER, OPEN-LABEL, PHASE 2 STUDY TO EVALUATE SAFETY AND EFFICACY OF U3-1402 IN SUBJECTS WITH ADVANCED OR METASTATIC COLORECTAL CANCER (CRC) Phase II Principal Investigator Pedersen, Katrina Disease Site Colon; Rectum Learn more about…

202011055

A Randomized Phase III Study of Immune Checkpoint Inhibition with Chemotherapy in Treatment-Naïve Metastatic Anal Cancer Patients Phase III Principal Investigator Aranha, Olivia Disease Site Anus Learn more about this study at: clinicaltrials.gov

202103218

Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy (IMPT) in the Reirradiation of Locoregionally Recurrent Rectal Cancer – IMPARC Phase N/A Principal Investigator Badiyan, Shahed Disease Site Anus; Colon; Rectum Learn more about this study at: clinicaltrials.gov