Metabolomics Shared Resource (MSR@MTAC)

The Siteman Cancer Center (SCC) Metabolomics Shared Resource at Mass Spectrometry Technology Access Center (MSR@MTAC) is dedicated to the comprehensive qualitative and quantitative detection of cellular components, particularly focusing on metabolites and lipids. Through the implementation of cutting-edge technologies, the center offers services for both global and targeted metabolomics/lipidomics analyses. Embracing the philosophy of ‘precision -omics,’ MTAC utilizes high-performance mass spectrometry to achieve precise identification and quantification of small molecules and lipids with exceptional confidence.

The Metabolomics Core at MTAC provides a range of services across six main areas: 1) Untargeted Metabolomics Profiling; 2) Targeted Metabolomics Assay; 3) Untargeted Lipidomics Profiling; 4) Targeted Lipidomics Assay; 5) Metabolic Flux Analysis using Stable Isotope Tracing; and 6) Custom Assay Development

The following Specific Aims will direct accomplishment of these overarching goals:

Aim 1: Establishing Comprehensive Metabolomic Profiling: The primary aim of the newly established Metabolomics Core at Washington University for Siteman Cancer Center (SCC) is to provide comprehensive metabolomic profiling services. This includes the analysis of a wide range of metabolites in biological samples, enabling researchers to gain insights into metabolic pathways relevant to cancer biology. By offering state-of-the-art instrumentation and expertise, the core aims to facilitate in-depth investigations into the metabolic alterations associated with cancer development, progression, and response to therapy.

Aim 2: Supporting Custom Assay Development for Targeted Metabolomics: In addition to comprehensive metabolomic profiling, the Metabolomics Core is dedicated to supporting targeted metabolomics studies that require the development of custom assays to quantify specific sets of metabolites. Recognizing the diverse metabolic pathways and unique research needs of investigators at SCC, the core aims to collaborate closely with researchers to design and optimize assays tailored to their specific targets of interest. This includes the validation of analytical methods, optimization of sample preparation protocols, and implementation of quality control measures to ensure the accuracy and reproducibility of results. By providing expertise in assay development and customization, the core aims to empower researchers to investigate targeted metabolic pathways relevant to cancer biology and therapeutics, ultimately advancing our understanding of metabolic dysregulation in cancer and facilitating the discovery of novel therapeutic interventions.

Aim 3: Facilitating Translational Research: The Metabolomics Core aims to support translational research efforts within SCC by offering metabolomic profiling services for both preclinical models and clinical samples. By collaborating closely with investigators, the core aims to facilitate the translation of basic research findings into clinically relevant applications. This includes identifying metabolic biomarkers for early cancer detection, predicting treatment response, and monitoring disease progression. Furthermore, the core aims to contribute to the development of personalized therapeutic strategies based on metabolic signatures, ultimately improving patient outcomes in the fight against cancer.

LOCATION: 4444 Forest Park, Room 4200

PRICING: Rates available here: CCSG members receive a 5% subsidy on major services.

TO ACCESS: Email [email protected]; Call 314-273-3483; Visit website:

NIH PUBLIC ACCESS POLICY: As of April 7, 2008, the NIH requires investigators with a publication using Siteman (or other NIH-funded) shared resources to submit (or have submitted for them) their final, peer reviewed manuscripts to PubMed Central(PMC) upon acceptance of publication, to be made publicly available within 12 months of publication. Many journals automatically submit these for authors, but Washington University also has assistance available through the Becker Medical Library. Please see,upon%20acceptance%20of%20the%20publication for more information.