Biorepository and Biospecimen Resource (BBR)

Formerly called the Tissue Procurement Core (TPC), the Biorepository and Biospecimen Resource (BBR) provides a centralized resource to process, store, and utilize biospecimens for translational and biomedical research.

Leadership: Mark Watson, MD, PhD

The Biorepository and Biospecimen Resource (BBR) is a shared resource supported by the Siteman Cancer Center and provides research programs and researchers with a centralized resource to process, store and utilize biospecimens for translational cancer and non-cancer biomedical research.

The BBR occupies 5,000 sq ft of wet-lab space on the fifth floor of the BJC Institute of Health (BJCIH) and an additional 2,800 sq ft of space at an off-site facility that supports secure and monitored long-term biospecimen storage.

The BBR maintains an archive of patient-matched malignant, non-malignant fixed and frozen tissues and biofluids for pilot, IRB-approved, retrospective correlative science studies, can assist investigators in the prospective collection, processing and storage of biospecimens from participants enrolled on clinical studies, and facilitates the use of biospecimens and their derivatives for genomic, molecular, metabolomic, and other translational research.

Dedicated staff and facilities generate bio-fluid, tissue, nucleic acid, single cell/nuclei, exosome and histological derivatives from patient-derived specimens. Services to facilitate tissue-based translational research such as laser capture microdissection, along with pathology consultation and digital imaging resources, are also available.

See the BBR website for more details on core services, resources and facilities.

LOCATION: BJC Institute of Health, 5th floor, Rms. 5120, 5113, 5205

PRICING: Please contact the core for current pricing of services offered.

TO ACCESS: Call 314-454-7605 or e-mail [email protected]

Request Biospecimens or Services from the BBR:

Existing users can login to OpenSpecimen and use Projects directly at https://openspecimen.wustl.edu/

New users can obtain training through Learn@Work and request an OpenSpecimen account by contacting [email protected].

Browse Existing Collections of Biospecimens using Open Specimen Catalogs – https://openspecimen.wusm.wustl.edu/openspecimen/#/specimen-catalogs/41/search

NIH PUBLIC ACCESS POLICY: As of April 7, 2008, the NIH requires investigators with a publication using Siteman (or other NIH-funded) shared resources to submit (or have submitted for them) their final, peer reviewed manuscripts to PubMed Central(PMC) upon acceptance of publication, to be made publicly available within 12 months of publication. Many journals automatically submit these for authors, but Washington University also has assistance available through the Becker Medical Library. Please see https://becker.wustl.edu/services/author-analytics-and-support/compliance/#:~:text=The%20NIH%20Public%20Access%20Policy,upon%20acceptance%20of%20the%20publication for more information.

PUBLICATION ACKNOWLEDGEMENT: If research supported by the Biorepository and Biospecimen Resource (BBR) results in publication, please acknowledge this support by including the following in your publication(s):

We thank the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, MO. and the Institute of Clinical and Translational Sciences (ICTS) at Washington University in St. Louis, for the use of the Biorepository and Biospecimen Resource, which provided __________ service. The Siteman Cancer Center is supported in part by an NCI Cancer Center Support Grant #P30 CA091842 and the ICTS is funded by the National Institutes of Health’s NCATS Clinical and Translational Science Award (CTSA) program grant #UL1 TR002345.