Imaging and Response Assessment Core (IRAC)


Barry Siegel, MD
Marilyn Siegel, MD

Website: Please click here for additional core information

Imaging methods are critically important in cancer clinical trials to define disease extent and to assess response of the cancer to treatment. The Imaging and Response Assessment Core (IRAC) is a shared resource that focuses on accurate and reproducible imaging assessment for tumor characterization and for determining response to therapy in clinical cancer research. Great care is taken to ensure the service provides accurate measurements of CT, MRI and PET/CT imaging data and that the services are delivered in a timely fashion. All results are reviewed by a board-certified radiologist.

The IRAC can accommodate a wide variety of study protocols that require tumor imaging and response assessment. The services available for these studies include:

  • Expert advice on how to integrate imaging into research study designs, and protocol development
  • Assistance in identifying the image response assessment criteria and personnel needed to support a particular study
  • Site qualification for imaging for cooperative group and industry-sponsored multicenter clinical trials
  • Research coordinator services required for execution of specialized imaging examinations
  • Coordination of the response assessment activities and reporting, including data interception at the time of acquisition and subsequent routing to appropriate workflow lists for processing
  • Actual measurement of radiologic data used to evaluate tumor response with oversight and signoff by a trained radiologist and/or nuclear medicine physician.

LOCATION: Please contact this shared resource directly for physical location.

PRICING: Please contact the core for current pricing of services offered.

TO ACCESS: contact Lora Gallagher, 314-747-4065 or email

IRAC Lymphoma Review Request

IRAC Review Request

IRAC Service Expectations Information

NIH PUBLIC ACCESS POLICY: As of April 7, 2008, the NIH requires investigators with a publication using Siteman (or other NIH-funded) shared resources to submit (or have submitted for them) their final, peer reviewed manuscripts to PubMed Central(PMC) upon acceptance of publication, to be made publicly available within 12 months of publication. Many journals automatically submit these for authors, but Washington University also has assistance available through the Becker Medical Library. Please see or for more information.

PUBLICATION ACKNOWLEDGEMENT: If research supported by the Imaging and Response Assessment Core results in publication, please acknowledge this support by including the following in your publication(s):

We thank the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, MO., for the use of the Imaging and Response Assessment Core, which provided __________ service. The Siteman Cancer Center is supported in part by an NCI Cancer Center Support Grant #P30 CA091842.